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Human postburn oedema measured with the impression method
Department of Biomedical Engineering, Umeå University Hospital and Linköping University, Sweden.
Linköpings universitet, Institutionen för medicin och vård, Anestesiologi. Linköpings universitet, Hälsouniversitetet.
Linköpings universitet, Institutionen för klinisk och experimentell medicin, Brännskadevård. Linköpings universitet, Hälsouniversitetet.
Linköpings universitet, Institutionen för klinisk och experimentell medicin, Kirurgi. Linköpings universitet, Hälsouniversitetet.
1993 (engelsk)Inngår i: Burns, ISSN 0305-4179, E-ISSN 1879-1409, Vol. 19, nr 6, s. 479-489Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

The course of tissue swelling in human non-injured skin after burn injury was investigated with a non-invasive impression method that measures force and tissue fluid translocation during mechanical compression of the skin. Time-dependent changes in the fluid translocation and the interstitial-pressure related to impression force were measured on 11 occasions, during 3 weeks, in seven patients postburn. A mathematical model was fitted to the impression force curves and the parameters of the model depicted the time-dependent compartmental fluid shift in the postburn generalized oedema. Tissue fluid translocation increased significantly (P < 0.05) up to a maximum value after 6 days postburn and declined thereafter. This indicated a continuous increase in the generalized postburn oedema for the first 6 days postburn. Impression force at 3 weeks postburn was significantly lower (P < 0.001) as compared with the half-day postburn value, indicating an increased tissue pressure during the first days postburn. Parameter analysis indicated a flux of water-like fluid from the vasculature to the interstitial space during the first 6 days postburn. The spread of the values registered between different measurement sites was, however, large.

sted, utgiver, år, opplag, sider
1993. Vol. 19, nr 6, s. 479-489
HSV kategori
Identifikatorer
URN: urn:nbn:se:liu:diva-79563DOI: 10.1016/0305-4179(93)90003-QOAI: oai:DiVA.org:liu-79563DiVA, id: diva2:543581
Tilgjengelig fra: 2012-08-08 Laget: 2012-08-08 Sist oppdatert: 2017-12-07bibliografisk kontrollert
Inngår i avhandling
1. Water physiology in burn victims
Åpne denne publikasjonen i ny fane eller vindu >>Water physiology in burn victims
2000 (engelsk)Doktoravhandling, med artikler (Annet vitenskapelig)
Abstract [en]

Patients who sustain a burn injury of more than 20 - 30 % TBSA will, if untreated, develop burn shock within a couple of hours. Flcid is lost fi·om the vascular compartment due to suction from the interstitium of the wound and due to a generalised increase in vascular permeability. To prevent bum shock intravenous fluids are given during the first two days after a bum in order to ensure adequate organ perfusion. Although organ perfusion will be improved when blood volume is restored, the fluid provided will add to the continuing leak into the tissues. With fluid treatment the patient survives the acute stage, but the resulting oedema interferes with the healing of the burn wound and partially damaged skin may be further compromised.

To describe, follow and understand the development of the general oedema in burn injured patients we used four different techniques. Ethanol dilution was used for measurement of total body water (TBW), iohexol dilution in order to estimate extracellular volume (ECV), bioimpedance analysis (BIA) to register TBW as well as electrical membrane properties and the impression method (IM) for the measurement of visco-elastic properties in non-burned tissues. In order to further examine the non-invasive techniques (BIA and IM) these were used in patients subjected to haemodialysis.

The excess fluid was found to be accumulated in the extracellular space. Interesting alterations in the visco-clastic properties of the skin and cellular electrical membrane properties could also be detected. These alterations were not related to the actual tluid volume in the tissues. Instead, they were related to changes in the fluid equilibrium of the tissues. Still, one week postbum an excess of tissue fluid, altered cellular electrical membrane properties and changed visco-elastic properties of the skin remained.

Albumin supplementation did not influence the amount or distribution of the excess tissue fluid, measured with dilution techniques.

sted, utgiver, år, opplag, sider
Linköping: Linköpings universitet, 2000. s. 61
Serie
Linköping University Medical Dissertations, ISSN 0345-0082 ; 633
Emneord
Total body water, Extracellular fluid, Burn, Bioelectrical impedance, Oedema, Extracellular matrix
HSV kategori
Identifikatorer
urn:nbn:se:liu:diva-27560 (URN)12222 (Lokal ID)91-7219-734-X (ISBN)12222 (Arkivnummer)12222 (OAI)
Disputas
2000-05-27, Berzeliussalen, Universitetssjukhuset, Linköping, 08:30 (svensk)
Opponent
Tilgjengelig fra: 2009-10-08 Laget: 2009-10-08 Sist oppdatert: 2015-06-09bibliografisk kontrollert

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