liu.seSearch for publications in DiVA
Endre søk
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Meniscectomy in the rabbit knee leads to increased bone remodelling and cartilage degeneration within three weeks
Linköpings universitet, Institutionen för nervsystem och rörelseorgan, Ortopedi och Idrottsmedicin. Linköpings universitet, Hälsouniversitetet.
Linköpings universitet, Institutionen för nervsystem och rörelseorgan, Ortopedi och Idrottsmedicin. Linköpings universitet, Hälsouniversitetet.
Linköpings universitet, Institutionen för nervsystem och rörelseorgan, Ortopedi och Idrottsmedicin. Linköpings universitet, Hälsouniversitetet.
(engelsk)Manuskript (preprint) (Annet vitenskapelig)
Abstract [en]

Increased knowledge about the early cartilaginous and osseous responses to meniscectomy may elucidate processes behind development of osteoarthrosis. The purpose of the present study was to evaluate tibial bone and cartilage changes during the first months after meniscectomy.

Thirty-one skeletally mature New Zealand white rabbits were operated on with meniscectomy in the right knee and a sham-operation in the left knee. Another 12 rabbits were used as controls. The knee joints were evaluated 3, 6 and 12 weeks after surgery by radiolabelled bisphosphonate uptake (99mTc-HDP) and semiquantitative grading of histological changes in the subchondral bone and cartilage.

Already 3 weeks after meniscectomy, there was increased metabolic activity in the subchondral bone, and articular cartilage fibrillation. Similar changes were seen in shamoperated knees, but to a lesser extent. This appears to be caused both by the new loading situation in the joint after meniscectomy and the operative trauma.

HSV kategori
Identifikatorer
URN: urn:nbn:se:liu:diva-84496OAI: oai:DiVA.org:liu-84496DiVA, id: diva2:559783
Tilgjengelig fra: 2012-10-10 Laget: 2012-10-10 Sist oppdatert: 2012-10-10bibliografisk kontrollert
Inngår i avhandling
1. Early knee osteoarthrosis after meniscectomy: studies in rabbits
Åpne denne publikasjonen i ny fane eller vindu >>Early knee osteoarthrosis after meniscectomy: studies in rabbits
2003 (engelsk)Doktoravhandling, med artikler (Annet vitenskapelig)
Abstract [en]

Post-traumatic osteoarthrosis develops after intraarticular injuries. It is a disease, which affects both articular cartilage and subchondral bone, and progresses over 10-20 years. Irreversible damage has often occurred by the time clinical diagnosis is possible. More knowledge about the early phase of the disease might yield measures to detect and delay or even prevent progression. This thesis evaluates changes in articular cartilage and subchondral bone at an early stage of post-traumatic osteoarthrosis.

Simultaneous changes in articular cartilage and subchondral bone were evaluated 3 to 40 weeks post-operatively in a rabbit meniscectomy model for post-traumatic osteoarthrosis. Rabbits were meniscectomized in the right knee and sham-operated in the left knee. Osteoarthrotic cartilage changes were evaluated by histology. Changes in the subchondral bone were evaluated by histology, scintimetry and dual-energy X-ray absorptiometry (DEXA). Joint space narrowing, and its utility as diagnostic tool at early stages of osteoarthrosis, was assessed with weight-bearing radiographs. The prognostic value of transforming growth factor-ßI (TGF-ß1) and proteoglycan fragment concentrations in the joint fluid at an early stage was also assessed.

We found slight cartilage changes and an increased metabolic activity in the subchondral bone as early as 3 weeks after meniscectomy. However, sham-operated knees displayed similar changes, although to a lesser degree. Cartilage fibrillation progressed at areas of high load within the meniscectomized knee joint. The subchondral bone showed a general response such as high scintimetric activity 3 weeks after surgery, and a decreased bone mineral density at later time points. Local adaptation in areas of high load within the subchondral bone was also seen. There was an increased osteoid content at the border between the cancellous bone and the marrow cavity already 3 weeks after meniscectomy, and at 13 weeks the subchondral bone plate was thickened. This thickening of the bone plate persisted up to 40 weeks. Joint space narrowing occurred after removal of the meniscus, but weight-bearing radiographs were not sensitive enough to measure early cartilage changes. Increased concentration of TGF-ß1 in the joint fluid at 3 weeks after surgery was associated with a higher degree of histological osteoarthrotic changes at a later time point.

Simultaneous changes in both cartilage and bone were apparent already 3 weeks after surgery, indicating that both tissues are involved from a very early stage. The localisation of cartilage changes illustrates that mechanical consequences of meniscectomy play a crucial role in progression of the disease. Surgical trauma resulted in increased release of TGF-ß1 at 3 weeks after surgery. This was found to be indicative for the severity of later osteoarthrosis. Thus, factors solely associated with the surgical trauma may also be important for the progression of osteoarthrosis.

sted, utgiver, år, opplag, sider
Linköping: Linköpings universitet, 2003. s. 55
Serie
Linköping University Medical Dissertations, ISSN 0345-0082 ; 795
HSV kategori
Identifikatorer
urn:nbn:se:liu:diva-28031 (URN)12791 (Lokal ID)91-7373-553-1 (ISBN)12791 (Arkivnummer)12791 (OAI)
Disputas
2003-06-05, Elsa Brändströms sal, Hälsouniversitet, Linköping, 13:00 (svensk)
Opponent
Tilgjengelig fra: 2009-10-08 Laget: 2009-10-08 Sist oppdatert: 2012-10-10bibliografisk kontrollert

Open Access i DiVA

Fulltekst mangler i DiVA

Personposter BETA

Fahlgren, AnnaMessner, KarolaAspenberg, Per

Søk i DiVA

Av forfatter/redaktør
Fahlgren, AnnaMessner, KarolaAspenberg, Per
Av organisasjonen

Søk utenfor DiVA

GoogleGoogle Scholar

urn-nbn

Altmetric

urn-nbn
Totalt: 153 treff
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf