liu.seSök publikationer i DiVA
Ändra sökning
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
LTBP-2 confers pleiotropic suppression and promotes dormancy in a growth factor permissive microenvironment in nasopharyngeal carcinoma
Hong Kong University of Science and Technology, Peoples R China .
University of Hong Kong, Peoples R China .
University of Hong Kong, Peoples R China .
University of Helsinki, Finland University of Helsinki, Finland .
Visa övriga samt affilieringar
2012 (Engelska)Ingår i: Cancer Letters, ISSN 0304-3835, E-ISSN 1872-7980, Vol. 325, nr 1, s. 89-98Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

This study identified LTBP-2 as a pleiotropic tumor suppressor in nasopharyngeal carcinoma, which safeguards against critical malignant behaviors of tumor cells. LTBP-2 expression was significantly decreased or lost in up to 100% of NPC cell lines (7/7) and 80% of biopsies (24/30). Promoter hypermethylation was found to be involved in LTBP-2 silencing. Using a tetracycline-regulated inducible expression system, we unveiled functional roles of LTBP-2 in suppressing colony formation, anchorage-independent growth, cell migration, angiogenesis, VEGF secretion, and tumorigenicity. Three-dimensional culture studies suggested the involvement of LTBP-2 in maintenance of tumor cell dormancy in a growth factor favorable microenvironment.

Ort, förlag, år, upplaga, sidor
Elsevier , 2012. Vol. 325, nr 1, s. 89-98
Nyckelord [en]
Latent transforming growth factor beta binding protein 2 (LTBP-2), Nasopharyngeal carcinoma (NPC), Anti-angiogenesis, Tumor suppression, Tumor cell dormancy, Metastatic growth
Nationell ämneskategori
Teknik och teknologier
Identifikatorer
URN: urn:nbn:se:liu:diva-84878DOI: 10.1016/j.canlet.2012.06.005ISI: 000308781600011OAI: oai:DiVA.org:liu-84878DiVA, id: diva2:564145
Anmärkning

Funding Agencies|University Grants Council|AoE/M-06/08|Finnish Cancer Foundation||Swedish Cancer Society||Swedish Research Council||Swedish Institute||Karolinska Institute||

Tillgänglig från: 2012-11-01 Skapad: 2012-10-26 Senast uppdaterad: 2017-12-07

Open Access i DiVA

Fulltext saknas i DiVA

Övriga länkar

Förlagets fulltext
Av organisationen
Institutionen för klinisk och experimentell medicinHälsouniversitetet
I samma tidskrift
Cancer Letters
Teknik och teknologier

Sök vidare utanför DiVA

GoogleGoogle Scholar

doi
urn-nbn

Altmetricpoäng

doi
urn-nbn
Totalt: 110 träffar
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf