liu.seSök publikationer i DiVA
Ändra sökning
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Functional Polymorphisms of FAS and FASL Gene andRisk of Breast Cancer – Pilot Study of 134 Cases
Zahedan University of Medical Sciences, Iran.
Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Science, Iran.
University of Manitoba, Winnipeg, Canada .
Zahedan University of Medical Science, Iran.
Visa övriga samt affilieringar
2013 (Engelska)Ingår i: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 8, nr 1, s. e53075-Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Fas/Fas ligand (FasL) system is one of the key apoptotic signaling entities in the extrinsic apoptotic pathway. De-regulation of this pathway, i.e. by mutations may prevent the immune system from the removal of newly-formed tumor cells, and thus lead to tumor formation. The present study investigated the association between −1377 G/A (rs2234767) and −670 A/G (rs1800682) polymorphisms in Fas as well as single nucleotide polymorphisms INV2nt −124 A/G (rs5030772) and −844 C/T (rs763110) in FasL in a sample of Iranian patients with breast cancer. This case-control study was done on 134 breast cancer patients and 152 normal women. Genomic DNA was extracted from whole blood samples. The polymorphisms were determined by using tetra-ARMS-PCR method. There was no significant difference in the genotype distribution of FAS rs2234767 polymorphism between cases and controls. FAS rs1800682, FASL rs5030772, and FASL rs763110 genotypes showed significant associations with an increasing risk of breast cancer (odds ratio OR = 3.18, P = 0.019; OR = 5.08, P = 0.012; OR = 2.40, P = 0.024, respectively). In conclusion, FAS rs2234767 was not associated with breast cancer risk. Though, FAS rs1800682, FASL rs5030772, and FASL rs763110 polymorphisms were associated with the risk of breast cancer in the examined population.

Ort, förlag, år, upplaga, sidor
Public Library of Science , 2013. Vol. 8, nr 1, s. e53075-
Nationell ämneskategori
Medicin och hälsovetenskap Medicinska och farmaceutiska grundvetenskaper Medicinsk genetik
Identifikatorer
URN: urn:nbn:se:liu:diva-89685DOI: 10.1371/journal.pone.0053075ISI: 000314705800031PubMedID: 23326385OAI: oai:DiVA.org:liu-89685DiVA, id: diva2:608918
Tillgänglig från: 2013-03-01 Skapad: 2013-03-01 Senast uppdaterad: 2018-10-08

Open Access i DiVA

fulltext(299 kB)486 nedladdningar
Filinformation
Filnamn FULLTEXT01.pdfFilstorlek 299 kBChecksumma SHA-512
5faa48de57e4b17851baa61c2642327e933136e9b77a0fc2bdd5cee025b101d19f9be6c55109a9f16407e3a709e9675d3a95997031bf5850302734dd0d191ddf
Typ fulltextMimetyp application/pdf

Övriga länkar

Förlagets fulltextPubMed

Personposter BETA

Chaabane, WiemJain, Mayur VilasLos, Marek Jan

Sök vidare i DiVA

Av författaren/redaktören
Chaabane, WiemJain, Mayur VilasLos, Marek Jan
Av organisationen
CellbiologiHälsouniversitetet
I samma tidskrift
PLoS ONE
Medicin och hälsovetenskapMedicinska och farmaceutiska grundvetenskaperMedicinsk genetik

Sök vidare utanför DiVA

GoogleGoogle Scholar
Totalt: 486 nedladdningar
Antalet nedladdningar är summan av nedladdningar för alla fulltexter. Det kan inkludera t.ex tidigare versioner som nu inte längre är tillgängliga.

doi
pubmed
urn-nbn

Altmetricpoäng

doi
pubmed
urn-nbn
Totalt: 428 träffar
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf