liu.seSearch for publications in DiVA
Endre søk
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Functional Polymorphisms of FAS and FASL Gene andRisk of Breast Cancer – Pilot Study of 134 Cases
Zahedan University of Medical Sciences, Iran.
Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Science, Iran.
University of Manitoba, Winnipeg, Canada .
Zahedan University of Medical Science, Iran.
Vise andre og tillknytning
2013 (engelsk)Inngår i: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 8, nr 1, s. e53075-Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Fas/Fas ligand (FasL) system is one of the key apoptotic signaling entities in the extrinsic apoptotic pathway. De-regulation of this pathway, i.e. by mutations may prevent the immune system from the removal of newly-formed tumor cells, and thus lead to tumor formation. The present study investigated the association between −1377 G/A (rs2234767) and −670 A/G (rs1800682) polymorphisms in Fas as well as single nucleotide polymorphisms INV2nt −124 A/G (rs5030772) and −844 C/T (rs763110) in FasL in a sample of Iranian patients with breast cancer. This case-control study was done on 134 breast cancer patients and 152 normal women. Genomic DNA was extracted from whole blood samples. The polymorphisms were determined by using tetra-ARMS-PCR method. There was no significant difference in the genotype distribution of FAS rs2234767 polymorphism between cases and controls. FAS rs1800682, FASL rs5030772, and FASL rs763110 genotypes showed significant associations with an increasing risk of breast cancer (odds ratio OR = 3.18, P = 0.019; OR = 5.08, P = 0.012; OR = 2.40, P = 0.024, respectively). In conclusion, FAS rs2234767 was not associated with breast cancer risk. Though, FAS rs1800682, FASL rs5030772, and FASL rs763110 polymorphisms were associated with the risk of breast cancer in the examined population.

sted, utgiver, år, opplag, sider
Public Library of Science , 2013. Vol. 8, nr 1, s. e53075-
HSV kategori
Identifikatorer
URN: urn:nbn:se:liu:diva-89685DOI: 10.1371/journal.pone.0053075ISI: 000314705800031PubMedID: 23326385OAI: oai:DiVA.org:liu-89685DiVA, id: diva2:608918
Tilgjengelig fra: 2013-03-01 Laget: 2013-03-01 Sist oppdatert: 2018-10-08

Open Access i DiVA

fulltext(299 kB)496 nedlastinger
Filinformasjon
Fil FULLTEXT01.pdfFilstørrelse 299 kBChecksum SHA-512
5faa48de57e4b17851baa61c2642327e933136e9b77a0fc2bdd5cee025b101d19f9be6c55109a9f16407e3a709e9675d3a95997031bf5850302734dd0d191ddf
Type fulltextMimetype application/pdf

Andre lenker

Forlagets fulltekstPubMed

Personposter BETA

Chaabane, WiemJain, Mayur VilasLos, Marek Jan

Søk i DiVA

Av forfatter/redaktør
Chaabane, WiemJain, Mayur VilasLos, Marek Jan
Av organisasjonen
I samme tidsskrift
PLoS ONE

Søk utenfor DiVA

GoogleGoogle Scholar
Totalt: 496 nedlastinger
Antall nedlastinger er summen av alle nedlastinger av alle fulltekster. Det kan for eksempel være tidligere versjoner som er ikke lenger tilgjengelige

doi
pubmed
urn-nbn

Altmetric

doi
pubmed
urn-nbn
Totalt: 431 treff
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf