liu.seSearch for publications in DiVA
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Secular Trends in Nosocomial Bloodstream Infections: Antibiotic-Resistant Bacteria Increase the Total Burden of Infection
University of Medical Centre Utrecht, Netherlands.
Geneva University Hospital and Medical Sch, Switzerland.
John Radcliffe Hospital, England.
Amphia Hospital, Netherlands.
Show others and affiliations
2013 (English)In: Clinical Infectious Diseases, ISSN 1058-4838, E-ISSN 1537-6591, Vol. 56, no 6, p. 798-805Article in journal (Refereed) Published
Abstract [en]

Background. It is unknown whether rising incidence rates of nosocomial bloodstream infections (BSIs) caused by antibiotic-resistant bacteria (ARB) replace antibiotic-susceptible bacteria (ASB), leaving the total BSI rate unaffected.

Methods. We investigated temporal trends in annual incidence densities (events per 100 000 patient-days) of nosocomial BSIs caused by methicillin-resistant Staphylococcus aureus (MRSA), ARB other than MRSA, and ASB in 7 ARB-endemic and 7 ARB-nonendemic hospitals between 1998 and 2007.

Results. 33 130 nosocomial BSIs (14% caused by ARB) yielded 36 679 microorganisms. From 1998 to 2007, the MRSA incidence density increased from 0.2 to 0.7 (annual increase, 22%) in ARB-nonendemic hospitals, and from 3.1 to 11.7 (annual increase, 10%) in ARB-endemic hospitals (P = .2), increasing the incidence density difference between ARB-endemic and ARB-nonendemic hospitals from 2.9 to 11.0. The non-MRSA ARB incidence density increased from 2.8 to 4.1 (annual increase, 5%) in ARB-nonendemic hospitals, and from 1.5 to 17.4 (annual increase, 22%) in ARB-endemic hospitals (P < .001), changing the incidence density difference from −1.3 to 13.3. Trends in ASB incidence densities were similar in both groups (P = .7). With annual increases of 3.8% and 5.4% of all nosocomial BSIs in ARB-nonendemic and ARB-endemic hospitals, respectively (P < .001), the overall incidence density difference of 3.8 increased to 24.4.

Conclusions.  Increased nosocomial BSI rates due to ARB occur in addition to infections caused by ASB, increasing the total burden of disease. Hospitals with high ARB infection rates in 2005 had an excess burden of BSI of 20.6 per 100 000 patient-days in a 10-year period, mainly caused by infections with ARB.

Place, publisher, year, edition, pages
Oxford University Press (OUP): Policy A1 , 2013. Vol. 56, no 6, p. 798-805
Keywords [en]
Trends, nosocomial, bloodstream infections, antibiotic-resistant bacteria, antibiotic-susceptible bacteria
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-90751DOI: 10.1093/cid/cis1006ISI: 000315630800012PubMedID: 23223600OAI: oai:DiVA.org:liu-90751DiVA, id: diva2:614703
Note

Funding Agencies|Netherlands Organization of Scientific Research|VICI NWO 918.76.611|Oxford National Institute for Health Research Biomedical Research Centre||Novartis||3M||Roche||Optimer Pharmaceuticals||Cepheid||bioMerieux||Astellas||Basilea||Bayer||Pfizer||Gilead||MSD||Oxoid||Wyeth||Siemens||Bruker||

Available from: 2013-04-05 Created: 2013-04-05 Last updated: 2017-12-06Bibliographically approved

Open Access in DiVA

fulltext(630 kB)647 downloads
File information
File name FULLTEXT01.pdfFile size 630 kBChecksum SHA-512
af4cc2a52b9fc25ce0d20e2ac01ca6af05d9730715cc337d4116e4de364c16cab234d742d0ac4947c49fb579f879321ebad0dff72460a164507e6eae8c3ebfab
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Authority records

Hanberger, Håkan

Search in DiVA

By author/editor
Hanberger, Håkan
By organisation
Infectious DiseasesFaculty of Health SciencesDepartment of Infectious Diseases in Östergötland
In the same journal
Clinical Infectious Diseases
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
Total: 647 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 619 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf