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Olympic boxing is associated with elevated levels of the neuronal protein tau in plasma
Sahlgrens University Hospital, Sweden .
Sahlgrens University Hospital, Sweden .
Sahlgrens University Hospital, Sweden .
Quanterix Corp, MA USA .
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2013 (Engelska)Ingår i: Brain Injury, ISSN 0269-9052, E-ISSN 1362-301X, Vol. 27, nr 4, s. 425-433Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Objectives: The aim of this study was to investigate if olympic (amateur) boxing is associated with elevation of brain injury biomarkers in peripheral blood compared to controls. less thanbrgreater than less thanbrgreater thanMaterials and methods: Thirty olympic boxers competing in at least 47 bouts were compared to 25 controls. Blood was collected from the controls at one occasion and from the boxers within 1-6 days after a bout and after a rest period of at least 14 days. Tau concentration in plasma was determined using a novel single molecule ELISA assay and S-100B, glial fibrillary acidic protein, brain-derived neurotrophic factor and amyloid beta 1-42 were determined using standard immunoassays. less thanbrgreater than less thanbrgreater thanResults: None of the boxers had been knocked-out during the bout. Plasma-tau was significantly increased in the boxers after a bout compared to controls (mean +/- SD, 2.46 +/- 5.10 vs. 0.79 +/- 0.961 ngL(-1), p = 0.038). The other brain injury markers did not differ between the groups. Plasma-tau decreased significantly in the boxers after a resting period compared to after a bout (p = 0.030). less thanbrgreater than less thanbrgreater thanConclusions: Olympic boxing is associated with elevation of tau in plasma. The repetitive minimal head injury in boxing may lead to axonal injuries that can be diagnosed with a blood test.

Ort, förlag, år, upplaga, sidor
Informa Healthcare , 2013. Vol. 27, nr 4, s. 425-433
Nyckelord [en]
Diffuse axonal injury, head injury, mild brain injury
Nationell ämneskategori
Medicin och hälsovetenskap
Identifikatorer
URN: urn:nbn:se:liu:diva-91933DOI: 10.3109/02699052.2012.750752ISI: 000316954300007OAI: oai:DiVA.org:liu-91933DiVA, id: diva2:619791
Anmärkning

Funding Agencies|Marianne and Marcus Wallenberg Foundation, Sweden||ALF Grants||County Council of Vastra Gotaland, Sweden||Sahlgrenska University Hospital, Gothenburg, Sweden||Gothenburg Medical Society, Sweden||ALF Grants, County Council of Ostergotland, Sweden||The Swedish Research Council||

Tillgänglig från: 2013-05-06 Skapad: 2013-05-06 Senast uppdaterad: 2017-12-06

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Marcusson, Jan

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