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Specification of absorbed dose to water using model-based dose calculation algorithms for treatment planning in brachytherapy
Linköpings universitet, Institutionen för medicin och hälsa, Medicinsk radiofysik. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Centrum för kirurgi, ortopedi och cancervård, Radiofysikavdelningen US.
Linköpings universitet, Institutionen för medicin och hälsa, Medicinsk radiofysik. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Centrum för kirurgi, ortopedi och cancervård, Radiofysikavdelningen US.ORCID-id: 0000-0003-0209-498X
2013 (Engelska)Ingår i: Physics in Medicine and Biology, ISSN 0031-9155, E-ISSN 1361-6560, Vol. 58, nr 8, s. 2561-2579Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Model-based dose calculation algorithms (MBDCAs), recently introduced in treatment planning systems (TPS) for brachytherapy, calculate tissue absorbed doses. In the TPS framework, doses have hereto been reported as dose to water and water may still be preferred as a dose specification medium. Dose to tissue medium D-med then needs to be converted into dose to water in tissue D-w,D- med. Methods to calculate absorbed dose to differently sized water compartments/cavities inside tissue, infinitesimal (used for definition of absorbed dose), small, large or intermediate, are reviewed. Burlin theory is applied to estimate photon energies at which cavity sizes in the range 1 nm-10 mm can be considered small or large. Photon and electron energy spectra are calculated at 1 cm distance from the central axis in cylindrical phantoms of bone, muscle and adipose tissue for 20, 50, 300 keV photons and photons from I-125, Yb-169 and Ir-192 sources; ratios of mass-collision-stopping powers and mass energy absorption coefficients are calculated as applicable to convert D-med into D-w,D- med for small and large cavities. Results show that 1-10 nm sized cavities are small at all investigated photon energies; 100 mu m cavities are large only at photon energies andlt;20 keV. A choice of an appropriate conversion coefficient D-w,D- med/D-med is discussed in terms of the cavity size in relation to the size of important cellular targets. Free radicals from DNA bound water of nanometre dimensions contribute to DNA damage and cell killing and may be the most important water compartment in cells implying use of ratios of mass -collision-stopping powers for converting D-med into D-w,D- med.

Ort, förlag, år, upplaga, sidor
Institute of Physics Publishing (IOPP), 2013. Vol. 58, nr 8, s. 2561-2579
Nationell ämneskategori
Medicin och hälsovetenskap
Identifikatorer
URN: urn:nbn:se:liu:diva-92604DOI: 10.1088/0031-9155/58/8/2561ISI: 000317185600012OAI: oai:DiVA.org:liu-92604DiVA, id: diva2:621701
Konferens
3rd European Workshop on Monte Carlo Treatment Planning (MCTP)
Tillgänglig från: 2013-05-16 Skapad: 2013-05-14 Senast uppdaterad: 2017-12-06

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Carlsson Tedgren, ÅsaAlm Carlsson, Gudrun

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Carlsson Tedgren, ÅsaAlm Carlsson, Gudrun
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Medicinsk radiofysikHälsouniversitetetRadiofysikavdelningen US
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Physics in Medicine and Biology
Medicin och hälsovetenskap

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