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The lysosome: from waste bag to potential therapeutic target
Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för cellbiologi. Linköpings universitet, Hälsouniversitetet.
Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för cellbiologi. Linköpings universitet, Hälsouniversitetet.
Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för cellbiologi. Linköpings universitet, Hälsouniversitetet.
Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för cellbiologi. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Diagnostikcentrum, Klinisk patologi och klinisk genetik.ORCID-id: 0000-0003-4075-159X
2013 (engelsk)Inngår i: Journal of Molecular Cell Biology, ISSN 1674-2788, E-ISSN 1759-4685, Vol. 5, nr 4, s. 214-226Artikkel, forskningsoversikt (Fagfellevurdert) Published
Abstract [en]

Lysosomes are ubiquitous membrane-bound intracellular organelles with an acidic interior. They are central for degradation and recycling of macromolecules delivered by endocytosis, phagocytosis, and autophagy. In contrast to the rather simplified view of lysosomes as waste bags, nowadays lysosomes are recognized as advanced organelles involved in many cellular processes and are considered crucial regulators of cell homeostasis. The function of lysosomes is critically dependent on soluble lysosomal hydrolases (e.g. cathepsins) as well as lysosomal membrane proteins (e.g. lysosome-associated membrane proteins). This review focuses on lysosomal involvement in digestion of intra- and extracellular material, plasma membrane repair, cholesterol homeostasis, and cell death. Regulation of lysosomal biogenesis and function via the transcription factor EB (TFEB) will also be discussed. In addition, lysosomal contribution to diseases, including lysosomal storage disorders, neurodegenerative disorders, cancer, and cardiovascular diseases, is presented.

sted, utgiver, år, opplag, sider
Oxford University Press (OUP): Policy B - Oxford Open Option D , 2013. Vol. 5, nr 4, s. 214-226
Emneord [en]
degradation, apoptosis, lysosomal membrane permeabilization, exocytosis, cholesterol
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Identifikatorer
URN: urn:nbn:se:liu:diva-97246DOI: 10.1093/jmcb/mjt022ISI: 000322914000002OAI: oai:DiVA.org:liu-97246DiVA, id: diva2:645787
Merknad

Funding Agencies|Swedish Research Council||Swedish Cancer Society||Signhild Engkvist foundation||

Tilgjengelig fra: 2013-09-05 Laget: 2013-09-05 Sist oppdatert: 2017-12-06

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