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Fe(III) distribution varies substantially within and between atherosclerotic plaques
Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV. Linköpings universitet, Institutionen för medicin och hälsa, Avdelningen för radiologiska vetenskaper. Linköpings universitet, Hälsouniversitetet.
Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för inflammationsmedicin. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Diagnostikcentrum, Klinisk patologi och klinisk genetik.ORCID-id: 0000-0001-6716-0314
Linköpings universitet, Institutionen för medicin och hälsa, Avdelningen för kardiovaskulär medicin. Linköpings universitet, Hälsouniversitetet.
Norwegian University of Science and Technology, Trondheim, Norway.
Vise andre og tillknytning
2014 (engelsk)Inngår i: Magnetic Resonance in Medicine, ISSN 0740-3194, E-ISSN 1522-2594, Vol. 2, nr 71, s. 885-892Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

PURPOSE:

Vulnerable atherosclerotic plaques are structurally weak and prone to rupture, presumably due to local oxidative stress. Redox active iron is linked to oxidative stress and the aim of this study was to investigate the distribution of Fe(III) in carotid plaques and its relation to vulnerability for rupture.

METHODS:

Atherosclerotic plaques from 10 patients (three asymptomatic and seven symptomatic) were investigated. Plaque vulnerability was classified using ultrasound and immunohistochemistry and correlated to Fe(III) measured by electron paramagnetic resonance spectroscopy.

RESULTS:

Large intra-plaque Fe(III) variations were found. Plaques from symptomatic patients had a higher Fe(III) concentration as compared with asymptomatic plaques (0.36 ± 0.21 vs. 0.06 ± 0.04 nmol Fe(III)/mg tissue, P < 0.05, in sections adjoining narrowest part of the plaques). All but one plaque from symptomatic patients showed signs of cap rupture. No plaque from asymptomatic patients showed signs of cap rupture. There was a significant increase in cap macrophages in plaques from symptomatic patients compared with asymptomatic patients (31 ± 11% vs. 2.3 ± 2.3%, P < 0.01).

CONCLUSION:

Fe(III) distribution varies substantially within atherosclerotic plaques. Plaques from symptomatic patients had significantly higher concentrations of Fe(III), signs of cap rupture and increased cap macrophage activity.

sted, utgiver, år, opplag, sider
United States: John Wiley & Sons, 2014. Vol. 2, nr 71, s. 885-892
Emneord [en]
atherosclerosis; oxidative stress; reactive oxygen species; iron; electron paramagnetic resonance
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Identifikatorer
URN: urn:nbn:se:liu:diva-98001DOI: 10.1002/mrm.24687ISI: 000330769700047PubMedID: 23447110OAI: oai:DiVA.org:liu-98001DiVA, id: diva2:651081
Tilgjengelig fra: 2013-09-24 Laget: 2013-09-24 Sist oppdatert: 2019-10-14

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Gustafsson, HåkanHallbeck, MartinEngström, MariaRosén, AndersZachrisson, Helene

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