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The international normalized ratio according to Owren in liver disease: Interlaboratory assessment and determination of international sensitivity index
Karolinska University Hospital, Sweden .
Karolinska University Hospital, Sweden .
Karolinska University Hospital, Sweden .
Karolinska University Hospital, Sweden .
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2013 (Engelska)Ingår i: Thrombosis Research, ISSN 0049-3848, E-ISSN 1879-2472, Vol. 132, nr 3, s. 346-351Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Introduction: The international normalized ratio (INR) is used to prioritize liver disease patients for transplantation. Previous studies have shown high interlaboratory variability in Quick-based INR determinations in samples of patients with liver disease. We assessed Owren-based INR reagents for analyzing INR in patients with liver disease. Further, we determined the difference between international sensitivity index (ISI) for patients on vitamin K antagonists (ISIVKA) and ISI for patients with liver disease (ISIliver). less thanbrgreater than less thanbrgreater thanPatients and Methods: Twenty patients with liver disease were included, 10 with INR 1.8-3.6 (group A1) and 10 with INR 1.2-1.5 (group C1). Plasma from these patients was analyzed for Owren-based INR in eight Swedish laboratories using either of following reagents: SPA+, Owrens PT or Nycotest PT. To determine ISI liver, the reference thromboplastin RBT/05 and additional 41 patients with liver disease and 20 normal controls were included. ISIVKA was determined according to the WHO procedure. The difference between the ISIVKA and ISIliver was calculated. less thanbrgreater than less thanbrgreater thanResults: The coefficients of variance for the Owren based INR methods were 6.2% in group A1, 3.9 % in group C1 and 5.3% for all patients. The difference between ISIVKA and ISIliver were -0.4%, -0.7% and -0.2% for SPA+, Owrens PT and Nycotest PT respectively. less thanbrgreater than less thanbrgreater thanConclusions: Interlaboratory variation in INR analyses according to Owren in patients with liver disease is low and the difference between ISIVKA and ISIliver is below 10% with this method. ISIVKA can therefore be used in the INR calibration, for the Owren reagents studied, when analyzing plasma from patients with liver disease.

Ort, förlag, år, upplaga, sidor
Elsevier , 2013. Vol. 132, nr 3, s. 346-351
Nyckelord [en]
INR, Prothrombin time, Liver disease, Liver transplantation, Severity of illness index, MELD
Nationell ämneskategori
Medicin och hälsovetenskap
Identifikatorer
URN: urn:nbn:se:liu:diva-98222DOI: 10.1016/j.thromres.2013.05.032ISI: 000324060400009OAI: oai:DiVA.org:liu-98222DiVA, id: diva2:653214
Anmärkning

Funding Agencies|Swedish Order of Freemasons||Samariten Foundation||Wera Ekstrom Foundation||Ronald McDonald House Charities||HRH Crownprincess Lovisa Foundation||Foundation for Childrens Hospital Huddinge||Foundation of Clinical Research at Karolinska Institutet||Swedish Society of Medicine||Foundation of Coagulation research at Karolinska Institutet||Sven Jerring Foundation||Lions research fund||Swedish Gastrointestinal Research Foundation||

Tillgänglig från: 2013-10-03 Skapad: 2013-10-03 Senast uppdaterad: 2017-12-06

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Kechagias, StergiosLindahl, Tomas

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Avdelningen för kardiovaskulär medicinHälsouniversitetetMagtarmmedicinska klinikenAvdelningen för mikrobiologi och molekylär medicinKlinisk kemi
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