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Sound-evoked radial strain in the hearing organ
Karolinska Institutet / Karolinska University Hospital, Stockholm, Sweden.
Karolinska Institutet / Karolinska University Hospital, Stockholm, Sweden.
Karolinska Institutet / Karolinska University Hospital, Stockholm, Sweden.
2007 (engelsk)Inngår i: Biophysical Journal, ISSN 0006-3495, E-ISSN 1542-0086, Vol. 93, nr 9, s. 3279-3284Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

The hearing organ contains sensory hair cells, which convert sound-evoked vibration into action potentials in the auditory nerve. This process is greatly enhanced by molecular motors that reside within the outer hair cells, but the performance also depends on passive mechanical properties, such as the stiffness, mass, and friction of the structures within the organ of Corti. We used resampled confocal imaging to study the mechanical properties of the low-frequency regions of the cochlea. The data allowed us to estimate an important mechanical parameter, the radial strain, which was found to be 0.1% near the inner hair cells and 0.3% near the third row of outer hair cells during moderate-level sound stimulation. The strain was caused by differences in the motion trajectories of inner and outer hair cells. Motion perpendicular to the reticular lamina was greater at the outer hair cells, but inner hair cells showed greater radial vibration. These differences led to deformation of the reticular lamina, which connects the apex of the outer and inner hair cells. These results are important for understanding how the molecular motors of the outer hair cells can so profoundly affect auditory sensitivity.

sted, utgiver, år, opplag, sider
Cell Press , 2007. Vol. 93, nr 9, s. 3279-3284
HSV kategori
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URN: urn:nbn:se:liu:diva-101065DOI: 10.1529/biophysj.107.105072PubMedID: 17604314OAI: oai:DiVA.org:liu-101065DiVA, id: diva2:665152
Tilgjengelig fra: 2013-11-19 Laget: 2013-11-19 Sist oppdatert: 2018-01-11bibliografisk kontrollert

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