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Noise-induced alterations in cochlear mechanics, electromotility, and cochlear amplification
Karolinska Institutet, Stockholm, Sweden.
Karolinska Institutet, Stockholm, Sweden.
Karolinska Institutet, Stockholm, Sweden.
2013 (engelsk)Inngår i: Pflügers Archiv: European Journal of Physiology, ISSN 0031-6768, E-ISSN 1432-2013, Vol. 465, nr 6, s. 907-917Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Loud sounds are a common cause of hearing loss. Very intense sounds may result in permanent hearing loss, but lower levels typically cause a transient decrease in auditory sensitivity. Studies have arrived at different conclusions as regards the physiological mechanisms underlying such temporary threshold shifts. Here, we investigated the effect of acoustic overstimulation on the mechanics of the low-frequency areas of the guinea pig cochlea. We demonstrate that brief loud sound exposure results in an increased phase lag and a paradoxical frequency-specific increase of sound-evoked displacement. Despite the increased displacement, electrically evoked motion is reduced. Because electromotility is important for amplifying low-level sounds, this change was associated with a decrease in measures of cochlear amplification. These changes recovered over the course of 30-40 min. Overstimulation also caused an increase in cytoplasmic calcium levels of both hair cells and supporting cells. These data suggest that reduced organ of Corti stiffness contributes to temporary threshold shifts.

sted, utgiver, år, opplag, sider
Springer, 2013. Vol. 465, nr 6, s. 907-917
HSV kategori
Identifikatorer
URN: urn:nbn:se:liu:diva-101046DOI: 10.1007/s00424-012-1198-4PubMedID: 23247512OAI: oai:DiVA.org:liu-101046DiVA, id: diva2:665174
Tilgjengelig fra: 2013-11-19 Laget: 2013-11-19 Sist oppdatert: 2018-01-11bibliografisk kontrollert

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  • harvard1
  • ieee
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  • de-DE
  • en-GB
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  • nn-NB
  • sv-SE
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