liu.seSök publikationer i DiVA
Ändra sökning
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Ethanol-induced activation of AKT and DARPP-32 in the mouse striatum mediated by opioid receptors
National Institute on Alcohol Abuse and Alcoholism, NIH; Bethesda, MD, USA.
National Institute on Alcohol Abuse and Alcoholism, NIH; Bethesda, MD, USA.
National Institute on Alcohol Abuse and Alcoholism, NIH; Bethesda, MD, USA.
National Institute on Alcohol Abuse and Alcoholism, NIH; Bethesda, MD, USA.
Visa övriga samt affilieringar
2010 (Engelska)Ingår i: Addiction Biology, ISSN 1355-6215, E-ISSN 1369-1600, Vol. 15, nr 3, s. 299-303Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

The reinforcing properties of ethanol are in part attributed to interactions between opioid and dopaminergic signaling pathways, but intracellular mediators of such interactions are poorly understood. Here we report that an acute ethanol challenge induces a robust phosphorylation of two key signal transduction kinases, AKT and DARPP-32, in the striatum of mice. Ethanol-induced AKT phosphorylation was blocked by the opioid receptor antagonist naltrexone but unaffected by blockade of dopamine D2 receptors via sulpiride. In contrast, DARPP-32 phosphorylation was abolished by both antagonists. These data suggest that ethanol acts via two distinct but potentially synergistic striatal signaling cascades. One of these is D2-dependent, while the other is not. These findings illustrate that pharmacology of ethanol reward is likely more complex than that for other addictive drugs.

Ort, förlag, år, upplaga, sidor
Wiley-Blackwell, 2010. Vol. 15, nr 3, s. 299-303
Nyckelord [en]
Dopamine, ethanol, opioids, signal transduction, striatum
Nationell ämneskategori
Neurovetenskaper
Identifikatorer
URN: urn:nbn:se:liu:diva-101842DOI: 10.1111/j.1369-1600.2010.00212.xPubMedID: 20456289OAI: oai:DiVA.org:liu-101842DiVA, id: diva2:666728
Tillgänglig från: 2013-11-24 Skapad: 2013-11-24 Senast uppdaterad: 2018-01-11Bibliografiskt granskad

Open Access i DiVA

Fulltext saknas i DiVA

Övriga länkar

Förlagets fulltextPubMed

Personposter BETA

Thorsell, AnnikaHeilig, Markus

Sök vidare i DiVA

Av författaren/redaktören
Thorsell, AnnikaHeilig, Markus
I samma tidskrift
Addiction Biology
Neurovetenskaper

Sök vidare utanför DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetricpoäng

doi
pubmed
urn-nbn
Totalt: 126 träffar
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf