liu.seSearch for publications in DiVA
Endre søk
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Regulation of thalamocortical axon branching by BDNF and synaptic vesicle cycling
Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för cellbiologi. Linköpings universitet, Hälsouniversitetet. Osaka University, Suita, Japan.ORCID-id: 0000-0001-7526-923X
Osaka University, Suita, Japan.
Osaka University, Suita, Japan.
Osaka University, Suita, Japan.
Vise andre og tillknytning
2013 (engelsk)Inngår i: Frontiers in Neural Circuits, ISSN 1662-5110, E-ISSN 1662-5110, Vol. 7, nr 202Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

During development, axons form branches in response to extracellular molecules. Little is known about the underlying molecular mechanisms. Here, we investigate how neurotrophin-induced axon branching is related to synaptic vesicle cycling for thalamocortical axons. The exogenous application of brain-derived neurotrophic factor (BDNF) markedly increased axon branching in thalamocortical co-cultures, while removal of endogenous BDNF reduced branching. Over-expression of a C-terminal fragment of AP180 that inhibits clathrin-mediated endocytosis affected the laminar distribution and the number of branch points. A dominant-negative synaptotagmin mutant that selectively targets synaptic vesicle cycling, strongly suppressed axon branching. Moreover, axons expressing the mutant synaptotagmin were resistant to the branch-promoting effect of BDNF. These results suggest that synaptic vesicle cycling might regulate BDNF induced branching during the development of the axonal arbor.

sted, utgiver, år, opplag, sider
2013. Vol. 7, nr 202
Emneord [en]
Neocortex, development, BDNF, neurotrophin, axon branching, endocytosis, exocytosis, neurotransmitter release, synapse
HSV kategori
Identifikatorer
URN: urn:nbn:se:liu:diva-102341DOI: 10.3389/fncir.2013.00202ISI: 000328755400001OAI: oai:DiVA.org:liu-102341DiVA, id: diva2:676711
Forskningsfinansiär
Swedish Research Council, 2008-3050Swedish Research Council, 2008-2862Tilgjengelig fra: 2013-12-06 Laget: 2013-12-06 Sist oppdatert: 2018-01-25

Open Access i DiVA

fulltext(2548 kB)175 nedlastinger
Filinformasjon
Fil FULLTEXT01.pdfFilstørrelse 2548 kBChecksum SHA-512
a61c825acdecbd867472e781bd0630f2fb2849d93b9506152fe6647ef1f6d0b2f523e640ed7160417ca492b6474d3de06443c4edf3624bc652c4ba9cc7316909
Type fulltextMimetype application/pdf

Andre lenker

Forlagets fulltekst

Personposter BETA

Granseth, Björn

Søk i DiVA

Av forfatter/redaktør
Granseth, Björn
Av organisasjonen
I samme tidsskrift
Frontiers in Neural Circuits

Søk utenfor DiVA

GoogleGoogle Scholar
Totalt: 175 nedlastinger
Antall nedlastinger er summen av alle nedlastinger av alle fulltekster. Det kan for eksempel være tidligere versjoner som er ikke lenger tilgjengelige

doi
urn-nbn

Altmetric

doi
urn-nbn
Totalt: 141 treff
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf