liu.seSök publikationer i DiVA
Ändra sökning
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Clinical oxygen enhancement ratio of tumors in carbon ion radiotherapy: the influence of local oxygenation changes
Stockholm University, Sweden.
Stockholm University, Sweden.
Linköpings universitet, Institutionen för medicin och hälsa, Avdelningen för radiologiska vetenskaper. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Centrum för kirurgi, ortopedi och cancervård, Radiofysikavdelningen US.ORCID-id: 0000-0001-8171-2541
Aarhus University, Denmark.
Visa övriga samt affilieringar
2014 (Engelska)Ingår i: Journal of radiation research, ISSN 0449-3060, E-ISSN 1349-9157, Vol. 55, nr 5, s. 902-911Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

The effect of carbon ion radiotherapy on hypoxic tumors has recently been questioned because of low linear energy transfer (LET) values in the spread-out Bragg peak (SOBP). The aim of this study was to investigate the role of hypoxia and local oxygenation changes (LOCs) in fractionated carbon ion radiotherapy. Three-dimensional tumors with hypoxic subvolumes were simulated assuming interfraction LOCs. Different fractionations were applied using a clinically relevant treatment plan with a known LET distribution. The surviving fraction was calculated, taking oxygen tension, dose and LET into account, using the repairable–conditionally repairable (RCR) damage model with parameters for human salivary gland tumor cells. The clinical oxygen enhancement ratio (OER) was defined as the ratio of doses required for a tumor control probability of 50% for hypoxic and well-oxygenated tumors. The resulting OER was well above unity for all fractionations. For the hypoxic tumor, the tumor control probability was considerably higher if LOCs were assumed, rather than static oxygenation. The beneficial effect of LOCs increased with the number of fractions. However, for very low fraction doses, the improvement related to LOCs did not compensate for the increase in total dose required  for tumor control. In conclusion, our results suggest that hypoxia can influence the outcome of carbon ion radiotherapy because of the non-negligible oxygen effect at the low LETs in the SOBP. However, if LOCs occur, a relatively high level of tumor control probability is achievable with a large range of fractionation schedules for tumors with hypoxic subvolumes, but both hyperfractionation and hypofractionation should be pursued with caution.

Ort, förlag, år, upplaga, sidor
Oxford University Press, 2014. Vol. 55, nr 5, s. 902-911
Nyckelord [en]
hypoxia, OER, TCP, RCR, carbon ion, fractionation, LOC
Nationell ämneskategori
Cancer och onkologi
Identifikatorer
URN: urn:nbn:se:liu:diva-105890DOI: 10.1093/jrr/rru020ISI: 000342223100008PubMedID: 24728013OAI: oai:DiVA.org:liu-105890DiVA, id: diva2:711975
Tillgänglig från: 2014-04-11 Skapad: 2014-04-11 Senast uppdaterad: 2017-12-05

Open Access i DiVA

fulltext(1308 kB)277 nedladdningar
Filinformation
Filnamn FULLTEXT01.pdfFilstorlek 1308 kBChecksumma SHA-512
f20781af1a87ec7b83415447bfb46da08471715997ecf02f094660160de94ccec739e7b6ee0285b12cf9cde3f518756ae1522c79263239945858aabc3613c764
Typ fulltextMimetyp application/pdf

Övriga länkar

Förlagets fulltextPubMedOpen Access PDF (1271 kB)

Personposter BETA

Dasu, AlexandruFurusawa, YoshiyaToma-Dasu, Iuliana

Sök vidare i DiVA

Av författaren/redaktören
Dasu, AlexandruFurusawa, YoshiyaToma-Dasu, Iuliana
Av organisationen
Avdelningen för radiologiska vetenskaperHälsouniversitetetRadiofysikavdelningen US
I samma tidskrift
Journal of radiation research
Cancer och onkologi

Sök vidare utanför DiVA

GoogleGoogle Scholar
Totalt: 277 nedladdningar
Antalet nedladdningar är summan av nedladdningar för alla fulltexter. Det kan inkludera t.ex tidigare versioner som nu inte längre är tillgängliga.

doi
pubmed
urn-nbn

Altmetricpoäng

doi
pubmed
urn-nbn
Totalt: 1210 träffar
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf