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Outcome of 132 consecutive reconstructive operations for intestinal fistula--staged operation without primary anastomosis improved outcome in retrospective analysis
Falun County Hospital, Sweden .
Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för kliniska vetenskaper. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Centrum för kirurgi, ortopedi och cancervård, Kirurgiska kliniken US.
Karolinska University Hospital, Huddinge and CLINTEC, Karolinska Institute, Stockholm, Sweden .
Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för kliniska vetenskaper. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Centrum för kirurgi, ortopedi och cancervård, Kirurgiska kliniken US.
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2013 (engelsk)Inngår i: Scandinavian Journal of Surgery, ISSN 1457-4969, E-ISSN 1799-7267, Vol. 102, nr 3, s. 152-157Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

AIM

To study factors that influenced healing and survival after attempted closure of enterocutaneous fistula.

MATERIAL AND METHODS:

Retrospective analysis of prospective data concerning 101 patients operated on 132 instances for 110 enterocutaneous fistulae at two hospitals.

RESULTS:

In all, 96 (87%) of the 110 fistulae healed and 92 (91%) patients survived. A total of 9 patients with unhealed fistula died. Multivariate analysis revealed jaundice as an independent factor for both death and failed closure and operation without anastomosis as an independent positive factor for healing. Failure rate was lower after an operation with stoma without anastomosis (6 of 43, 14%) than after an operation with anastomosis (30 of 89, 34%) p = 0.0213. Of the 36 instances with unhealed fistula, 13 (36%) could be ascribed to inadvertent bowel lesions at the reconstructive operation. In addition, univariate analysis revealed that patients with previous multiple laparotomies or with multiple operations for enterocutaneous fistula healed less likely and had higher mortality. A low serum albumin, high white blood cell count, high C-reactive protein concentration, high fistula output, total parenteral nutrition, and operation for recurrent fistula were associated with death together with long operation time and operative bleeding, both indicators of surgical complexity. Over time, staged surgery avoiding anastomosis increased from 27% to 57%. Mortality decreased from 12% to 6%, and healing increased from 73% to 94%.

CONCLUSIONS:

Chronic inflammation, malnutrition, and liver failure causing an impaired healing capacity are important reasons for failure. Staged operation without primary anastomosis may allow the patient to reverse this condition and improve outcome. The high surgical complexity is a negative factor that requires careful planning of the operation.

sted, utgiver, år, opplag, sider
Sage Publications, 2013. Vol. 102, nr 3, s. 152-157
Emneord [en]
Surgery; bowel; fistula; anastomosis; stoma; enterocutaneous; wound healing; liver failure
HSV kategori
Identifikatorer
URN: urn:nbn:se:liu:diva-107130DOI: 10.1177/1457496913490452ISI: 000335583200004PubMedID: 23963028OAI: oai:DiVA.org:liu-107130DiVA, id: diva2:721994
Tilgjengelig fra: 2014-06-05 Laget: 2014-06-05 Sist oppdatert: 2017-12-05bibliografisk kontrollert

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Hallböök, OlofSjödahl, Rune

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