liu.seSearch for publications in DiVA
Endre søk
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Detection of lipoarabinomannan in urine for identification of active tuberculosis among HIV-positive adults in Ethiopian health centres
Lund University, Sweden Minist Heatlh, Ethiopia .
Lund University, Sweden Regional Department Infect Disease Control and Prevent, Sweden .
Clin Microbiol Regional and University of Labs, Sweden .
Lund University, Sweden .
Vise andre og tillknytning
2014 (engelsk)Inngår i: Tropical medicine & international health, ISSN 1360-2276, E-ISSN 1365-3156, Vol. 19, nr 6, s. 734-742Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

ObjectiveTo assess the diagnostic performance of urine lipoarabinomannan (LAM) detection for TB screening in HIV-positive adults in Ethiopia. MethodsTesting for LAM was performed using the Determine TB-LAM lateral flow assay on urine samples from participants in a prospective cohort with baseline bacteriological categorisation for active TB in sputum. Characteristics of TB patients with regard to LAM status were determined. Participants were followed for 6months to evaluate survival, retention in care and incident TB. ResultsPositive LAM results were found in 78/757 participants. Among 128 subjects with definite (confirmed by culture and/or Xpert MTB/RIF) TB, 33 were LAM-positive (25.8%); the respective figure for clinically diagnosed cases was 2/20 (10%). Five of the remaining 43 LAM-positive individuals had died during the 6-month follow-up period, whereas 38 remained in care without clinical signs of TB. The overall sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) were 25.8%, 92.9%, 42.3% and 86.0%, respectively. Among TB patients, LAM positivity was associated with higher WHO clinical stage, lower body mass index (BMI), CD4 cell and haemoglobin levels, and with increased mortality. A combination algorithm of urine LAM testing and sputum smear microscopy detected 49 (38.2%) of definite TB cases; among those with CD4 count 100cells/mm(3), this proportion was 66.7%. ConclusionsThe performance of urine LAM testing for TB detection was poor in this population. However, this was improved among subjects with CD4 count 100cells/mm(3). In combination with sputum microscopy urine, LAM could be considered for targeted TB screening in this subgroup.

sted, utgiver, år, opplag, sider
Wiley , 2014. Vol. 19, nr 6, s. 734-742
Emneord [en]
antiretroviral therapy; TB; lipoarabinomannan; Determine TB-LAM; health centres; Ethiopia; ART; tuberculose; lipoarabinomannane; determine TB-LAM; centres de sante; Ethiopie; TAR; TB; Lipoarabinomanano; Determinacion TB-LAM; centros sanitarios; Etiopia
HSV kategori
Identifikatorer
URN: urn:nbn:se:liu:diva-107447DOI: 10.1111/tmi.12308ISI: 000335234000013OAI: oai:DiVA.org:liu-107447DiVA, id: diva2:724327
Tilgjengelig fra: 2014-06-12 Laget: 2014-06-12 Sist oppdatert: 2018-01-11

Open Access i DiVA

Fulltekst mangler i DiVA

Andre lenker

Forlagets fulltekst

Personposter BETA

Schön, Thomas

Søk i DiVA

Av forfatter/redaktør
Schön, Thomas
Av organisasjonen
I samme tidsskrift
Tropical medicine & international health

Søk utenfor DiVA

GoogleGoogle Scholar

doi
urn-nbn

Altmetric

doi
urn-nbn
Totalt: 269 treff
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf