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Functional magnetic resonance imaging in narcolepsy and the Kleine–Levin syndrome
Linköpings universitet, Institutionen för medicin och hälsa, Avdelningen för radiologiska vetenskaper. Linköpings universitet, Hälsouniversitetet. Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV.ORCID-id: 0000-0002-2167-2450
Sahlgrenska Academy, University of Gothenburg, Sweden.
Sahlgrenska Academy, University of Gothenburg. Sweden; Halmstad County Hospital, Sweden.
Linköpings universitet, Institutionen för beteendevetenskap och lärande, Handikappvetenskap. Linköpings universitet, Filosofiska fakulteten. Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV. (Linnaeus Centre HEAD)
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2014 (engelsk)Inngår i: Frontiers in Neurology, ISSN 1664-2295, E-ISSN 1664-2295, Vol. 5, nr 105Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

This work aims at reviewing the present state of the art when it comes to understanding the pathophysiology of narcolepsy and the Kleine–Levin syndrome (KLS) from a neuroimaging point of view. This work also aims at discussing future perspectives of functional neuroimaging in these sleep disorders. We focus on functional magnetic resonance imaging (fMRI), which is a technique for in vivo measurements of brain activation in neuronal circuitries under healthy and pathological conditions. fMRI has significantly increased the knowledge on the affected neuronal circuitries in narcolepsy and the Kleine–Levin syndrome. It has been shown that narcolepsy is accompanied with disturbances of the emotional and the closely related reward systems. In the Kleine Levin syndrome, fMRI has identified hyperactivation of the thalamus as a potential biomarker that could be used in the diagnostic procedure. The fMRI findings in both narcolepsy and the Kleine–Levin syndrome are in line with previous structural and functional imaging studies. We conclude that fMRI in combination with multi-modal imaging can reveal important details about the pathophysiology in narcolepsy and the Kleine–Levin syndrome. In the future, fMRI possibly gives opportunities for diagnostic support and prediction of treatment response in individual patients.

sted, utgiver, år, opplag, sider
Switzerland: Frontiers Research Foundation , 2014. Vol. 5, nr 105
Emneord [en]
functional magnetic resonance imaging, narcolepsy, hypersomnia, Kleine–Levin syndrome, sleep, ascending arousal system, hypothalamus, thalamus
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Identifikatorer
URN: urn:nbn:se:liu:diva-109314DOI: 10.3389/fneur.2014.00105PubMedID: 25009530OAI: oai:DiVA.org:liu-109314DiVA, id: diva2:737310
Tilgjengelig fra: 2014-08-12 Laget: 2014-08-12 Sist oppdatert: 2017-12-05bibliografisk kontrollert

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