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Low wall stress in the popliteal artery: Other mechanisms responsible for the predilection of aneurysmal dilatation?
Jonköping Hospital, Sweden .
Jonköping Hospital, Sweden .
Lund University, Sweden .
Capio Lundby Hospital, Sweden .
Vise andre og tillknytning
2014 (engelsk)Inngår i: Vascular Medicine, ISSN 1358-863X, E-ISSN 1477-0377, Vol. 19, nr 2, s. 131-136Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

The popliteal artery (PA) is, after aorta, the most common site for aneurysm formation. Why the PA is more susceptible than other peripheral muscular arteries is unknown. We hypothesized that the wall composition, which in turn affects wall properties, as well as the circumferential wall stress (WS) imposed on the arterial wall, might differ compared to other muscular arteries. The aim was to study the WS of the PA in healthy subjects with the adjacent, muscular, common femoral artery (CFA) as a comparison. Ninety-four healthy subjects were included in this study (45 males, aged 10-78 years and 49 females, aged 10-83 years). The diameter and intima-media thickness (IMT) in the PA and CFA were investigated with ultrasound. Together with blood pressure the WS was defined according to the law of Laplace adjusted for IMT. The diameter increased with age in both PA and CFA (pless than0.001), with males having a larger diameter than females (pless than0.001). IMT increased with age in both PA and CFA (pless than0.001), with higher IMT values in males only in PA (pless than0.001). The calculated WS was unchanged with age in both arteries, but lower in PA than in CFA in both sexes (pless than0.001). In conclusion, this study shows that the PA and CFA WS is maintained during aging, probably due to a compensatory remodelling response with an increase in arterial wall thickness. However, the stress imposed on the PA wall is quite low, indicating that mechanisms other than WS contribute to the process of pathological arterial dilatation in the PA.

sted, utgiver, år, opplag, sider
SAGE Publications (UK and US) , 2014. Vol. 19, nr 2, s. 131-136
Emneord [en]
aneurysm; blood pressure; humans; popliteal artery
HSV kategori
Identifikatorer
URN: urn:nbn:se:liu:diva-110293DOI: 10.1177/1358863X14524851ISI: 000340162100008PubMedID: 24569643OAI: oai:DiVA.org:liu-110293DiVA, id: diva2:744012
Merknad

Funding Agencies|Swedish Research Council [12661]; Swedish Heart and Lung Foundation [20130650]; Futurum - the Academy for Healthcare, County Council, Jonkoping, Sweden [259701]; King Gustav V and Queen Victorias Foundation

Tilgjengelig fra: 2014-09-05 Laget: 2014-09-05 Sist oppdatert: 2017-12-05

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