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Turbulence Quantification of Stenotic Blood Flow Using Image-Based CFD: Effect of Different Interventions
Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Mekanisk värmeteori och strömningslära. Linköpings universitet, Tekniska högskolan.ORCID-id: 0000-0003-4656-7662
Linköpings universitet, Institutionen för teknik och naturvetenskap, Medie- och Informationsteknik. Linköpings universitet, Tekniska högskolan.ORCID-id: 0000-0003-1942-7699
Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Mekanisk värmeteori och strömningslära. Linköpings universitet, Tekniska högskolan. Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV.ORCID-id: 0000-0001-5526-2399
2014 (engelsk)Inngår i: WCB 2014, 2014Konferansepaper, Poster (with or without abstract) (Annet vitenskapelig)
Abstract [en]

Turbulent blood flow is often associated with some sort of cardiovascular disease, e.g. sharp bends and/or sudden constrictions/expansions of the vessel wall. The energy losses associated with the turbulent flow may increase the heart workload in order to maintain cardiac output (CO). In the present study, the amount of turbulent kinetic energy (TKE) developed in the vicinity of an aortic coarctation was estimated pre-intervention and in a variety of post-intervention configurations, using scale-resolved image-based computational fluid dynamics (CFD). TKE can be measured using magnet resonance imaging (MRI) and have also been validated with CFD simulations [1], i.e. a parameter that not only can be quantified using simulations but can also be measured by MRI.

Patient-specific geometry and inlet flow conditions were obtained using contrast-enhanced MR angiography and 2D cine phase-contrast MRI, respectively. The intervention procedure was mimicked using an inflation simulation, where six different geometries were obtained. A scale-resolving turbulence model, large eddy simulation (LES), was utilized to resolve the largest turbulent scales and also to capture the laminar-to-turbulent transition. All cases were simulated using baseline CO and with a 20% CO increase to simulate a possible flow adaption after intervention.

For this patient, results shows a non-linear decay of the total amount of TKE integrated over the cardiac phase as the stenotic cross-sectional area is increased by the intervention.  Figure 1 shows the original segmented geometry and two dilated coarctation with corresponding volume rendering of the TKE at peak systole. Due to turbulent transition at a kink upstream the stenosis further dilation of the coarctation tends to restrict the TKE to a plateau, and continued vessel expansion may therefore only induce unnecessary stresses onto the arterial wall. 

This patient-specific non-invasive framework has shown the geometrical impact on the TKE estimates. New insight in turbulence development indicates that the studied coarctation can only be improved to a certain extent, where focus should be on the upstream region, if further TKE reduction is motivated. The possibility of including MRI in a combined framework could have great potential for future intervention planning and follow-up studies.  

[1] J. Lantz, T. Ebbers, J. Engvall and M. Karlsson, Numerical and Experimental Assessment of Turbulent Kinetic Energy in an Aortic Coarctation, Journal of Biomechnics, 2013. 46(11): p. 1851-1858.

sted, utgiver, år, opplag, sider
2014.
Emneord [en]
Computational fluid dynamics, Large eddy simulation, Turbulent kinetic energy, Flow displacement, Non-Newtonian, Carreau, Virtual treatment, Magnetic resonance imaging
HSV kategori
Identifikatorer
URN: urn:nbn:se:liu:diva-111042OAI: oai:DiVA.org:liu-111042DiVA, id: diva2:752749
Konferanse
7th World Congress of Biomechanics (WCB 2014), July 6-11, 2014, Boston, Massachusetts, USA
Tilgjengelig fra: 2014-10-06 Laget: 2014-10-06 Sist oppdatert: 2016-03-14

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Andersson, MagnusLantz, JonasKarlsson, Matts

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