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A system for remote dosimetry audit of 3D-CRT, IMRT and VMAT based on lithium formate dosimetry
Linköpings universitet, Institutionen för medicin och hälsa, Avdelningen för radiologiska vetenskaper. Linköpings universitet, Hälsouniversitetet.
Linköpings universitet, Institutionen för medicin och hälsa, Avdelningen för radiologiska vetenskaper. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Diagnostikcentrum, Medicinsk teknik i Östergötland.
Linköpings universitet, Institutionen för medicin och hälsa, Avdelningen för radiologiska vetenskaper. Linköpings universitet, Hälsouniversitetet.
Linköpings universitet, Institutionen för medicin och hälsa, Avdelningen för radiologiska vetenskaper. Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Centrum för kirurgi, ortopedi och cancervård, Radiofysikavdelningen US.ORCID-id: 0000-0003-0209-498X
Vise andre og tillknytning
2014 (engelsk)Inngår i: Radiotherapy and Oncology, ISSN 0167-8140, E-ISSN 1879-0887, Vol. 113, nr 2, s. 279-282Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

The aim of this work was to develop and test a remote end-to-end audit system using lithium formate EPR dosimeters. Four clinics were included in a pilot study, absorbed doses determined in the PTV agreed with TPS calculated doses within ±5% for 3D-CRT and ±7% (k=1) for IMRT/VMAT dose plans.

sted, utgiver, år, opplag, sider
Elsevier, 2014. Vol. 113, nr 2, s. 279-282
Emneord [en]
Dosimetry audit; remote audit; end-to-end; EPR; ESR; lithium formate
HSV kategori
Identifikatorer
URN: urn:nbn:se:liu:diva-111089DOI: 10.1016/j.radonc.2014.11.027ISI: 000347657200021OAI: oai:DiVA.org:liu-111089DiVA, id: diva2:753200
Tilgjengelig fra: 2014-10-07 Laget: 2014-10-07 Sist oppdatert: 2017-12-05bibliografisk kontrollert
Inngår i avhandling
1. Lithium formate EPR dosimetry for accurate measurements of absorbed dose in radiotherapy
Åpne denne publikasjonen i ny fane eller vindu >>Lithium formate EPR dosimetry for accurate measurements of absorbed dose in radiotherapy
2014 (engelsk)Doktoravhandling, med artikler (Annet vitenskapelig)
Abstract [en]

Lithium formate has shown to be a material with properties suitable for electron paramagnetic resonance (EPR) dosimetry, among them up to 7 times higher sensitivity compared to alanine, which is a well-established EPR detector material for dose determinations in radiotherapy.

The aim of this thesis was to further investigate the properties of lithium formate and develop the dosimetry system towards applications in radiotherapy. The intrinsic efficiency for energies of relevance to brachytherapy and the signal stability were investigated. The dosimetry system was expanded to include a smaller dosimeter model, suitable for measurements in dose gradient regions. An individual sensitivity correction method was applied to the smaller dosimeters to be able to perform dose determinations with the same precision as for the larger ones. EPR dosimetry in general is time consuming and effort was spent to optimize the signal readout procedure regarding measurement time and measurement precision.

The system was applied in two clinical applications chosen for their high demands on the dosimetry system: 1) a dosimetry audit for external photon beam therapy and 2) dose verification measurements around a low energy HDR brachytherapy source.

The conclusions drawn from this thesis were: dose determinations can be performed with a standard uncertainty of 1.8-2.5% using both the original size dosimeters and the new developed smaller ones. The dosimetry system is robust and useful for applications when high measurement precision and accuracy is prioritized. It is a good candidate for dosimetry audits, both in external beam therapy and brachytherapy.

sted, utgiver, år, opplag, sider
Linköping: Linköping University Electronic Press, 2014. s. 51
Serie
Linköping University Medical Dissertations, ISSN 0345-0082 ; 1417
HSV kategori
Identifikatorer
urn:nbn:se:liu:diva-111091 (URN)10.3384/diss.diva-111091 (DOI)978-91-7519-246-8 (ISBN)
Disputas
2014-11-06, Eken, ingång 65, plan 9, Campus US, Linköpings universitet, Linköping, 09:00 (engelsk)
Opponent
Veileder
Tilgjengelig fra: 2014-10-07 Laget: 2014-10-07 Sist oppdatert: 2019-11-18bibliografisk kontrollert

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