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URBAN WASTEWATER EFFLUENT INCREASES ANTIBIOTIC RESISTANCE GENE CONCENTRATIONS IN A RECEIVING NORTHERN EUROPEAN RIVER
Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för mikrobiologi och molekylär medicin. Linköpings universitet, Hälsouniversitetet.
Umeå University, Sweden.
Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för mikrobiologi och molekylär medicin. Linköpings universitet, Hälsouniversitetet. County Hospital Ryhov, Sweden.
2015 (Engelska)Ingår i: Environmental Toxicology and Chemistry, ISSN 0730-7268, E-ISSN 1552-8618, Vol. 34, nr 1, s. 192-196Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Antibiotic-resistant bacteria are an emerging global problem that threatens to undermine important advances in modern medicine. The environment is likely to play an important role in the dissemination of antibiotic-resistance genes (ARGs) among both environmental and pathogenic bacteria. Wastewater treatment plants (WWTPs) accumulate both chemical and biological waste from the surrounding urban milieu and have therefore been viewed as potential hotspots for dissemination and development of antibiotic resistance. To assess the effect of wastewater effluent on a river that flows through a Swedish city, sediment and water samples were collected from Stangan River, both upstream and downstream of an adjacent WWTP over 3 mo. Seven ARGs and the integrase gene on class 1 integrons were quantified in the collected sediment using real-time polymerase chain reaction (PCR). Liquid chromatography-mass spectrometry was used to assess the abundance of 10 different antibiotics in the water phase of the samples. The results showed an increase in ARGs and integrons downstream of the WWTP. The measured concentrations of antibiotics were low in the water samples from the Stangan River, suggesting that selection for ARGs did not occur in the surface water. Instead, the downstream increase in ARGs is likely to be attributable to accumulation of genes present in the treated effluent discharged from the WWTP. Environ Toxicol Chem 2015;34:192-196. (c) 2014 SETAC

Ort, förlag, år, upplaga, sidor
Wiley: 12 months , 2015. Vol. 34, nr 1, s. 192-196
Nyckelord [en]
Antibiotic resistance genes; Antibiotics; Integrons; Quantitative real-time PCR; Wastewater
Nationell ämneskategori
Klinisk medicin
Identifikatorer
URN: urn:nbn:se:liu:diva-113727DOI: 10.1002/etc.2784ISI: 000346789800024PubMedID: 25331227OAI: oai:DiVA.org:liu-113727DiVA, id: diva2:784631
Anmärkning

Funding Agencies|Swedish Research Council for Environment, Agricultural Sciences, and Spatial Planning (Formas) [210-2006-2132]; Foundation for Strategic Environmental Research (MISTRA; within the research project MISTRAPHARMA)

Tillgänglig från: 2015-01-30 Skapad: 2015-01-29 Senast uppdaterad: 2017-12-05

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Berglund, BjörnLindgren, Per-Eric

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