liu.seSök publikationer i DiVA
Ändra sökning
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
A tandem repeat in decay accelerating factor 1 is associated with severity of murine mercury-induced autoimmunity
Department of Surgery, University of California, San Diego, 9500 Gilman Drive, No. 0739, La Jolla, CA 92093-0739, USA.
Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA.
Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för inflammationsmedicin. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Diagnostikcentrum, Klinisk patologi och klinisk genetik.
Visa övriga samt affilieringar
2014 (Engelska)Ingår i: Autoimmune Diseases, ISSN 2090-0422, E-ISSN 2090-0430, Vol. 2014, nr 260613Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Decay accelerating factor (DAF), a complement-regulatory protein, protects cells from bystander complement-mediated lysis and negatively regulates T cells. Reduced expression of DAF occurs in several systemic autoimmune diseases including systemic lupus erythematosus, and DAF deficiency exacerbates disease in several autoimmune models, including murine mercury-induced autoimmunity (mHgIA). Daf1, located within Hmr1, a chromosome 1 locus associated in DBA/2 mice with resistance to mHgIA, could be a candidate. Here we show that reduced Daf1 transcription in lupus-prone mice was not associated with a reduction in the Daf1 transcription factor SP1. Studies of NZB mice congenic for the mHgIA-resistant DBA/2 Hmr1 locus suggested that Daf1 expression was controlled by the host genome and not the Hmr1 locus. A unique pentanucleotide repeat variant in the second intron of Daf1 in DBA/2 mice was identified and shown in F2 intercrosses to be associated with less severe disease; however, analysis of Hmr1 congenics indicated that this most likely reflected the presence of autoimmunity-predisposing genetic variants within the Hmr1 locus or that Daf1 expression is mediated by the tandem repeat in epistasis with other genetic variants present in autoimmune-prone mice. These studies argue that the effect of DAF on autoimmunity is complex and may require multiple genetic elements.

Ort, förlag, år, upplaga, sidor
Hindawi Publishing Corporation, 2014. Vol. 2014, nr 260613
Nationell ämneskategori
Medicinsk genetik
Identifikatorer
URN: urn:nbn:se:liu:diva-116712DOI: 10.1155/2014/260613PubMedID: 24818014Scopus ID: 2-s2.0-84900019378OAI: oai:DiVA.org:liu-116712DiVA, id: diva2:800103
Tillgänglig från: 2015-04-01 Skapad: 2015-04-01 Senast uppdaterad: 2018-01-16

Open Access i DiVA

fulltext(2086 kB)136 nedladdningar
Filinformation
Filnamn FULLTEXT01.pdfFilstorlek 2086 kBChecksumma SHA-512
3039da7cabd8ec61ae9d3c5b58fa5a92f0fe838cf10346ec926f668e465011bf7a9736c4ddaf75d1324348fdfecf502087eadffb165d09fd4879645d4ec33dff
Typ fulltextMimetyp application/pdf

Övriga länkar

Förlagets fulltextPubMedScopus

Personposter BETA

Hultman, Per

Sök vidare i DiVA

Av författaren/redaktören
Hultman, Per
Av organisationen
Avdelningen för inflammationsmedicinHälsouniversitetetKlinisk patologi och klinisk genetik
I samma tidskrift
Autoimmune Diseases
Medicinsk genetik

Sök vidare utanför DiVA

GoogleGoogle Scholar
Totalt: 136 nedladdningar
Antalet nedladdningar är summan av nedladdningar för alla fulltexter. Det kan inkludera t.ex tidigare versioner som nu inte längre är tillgängliga.

doi
pubmed
urn-nbn

Altmetricpoäng

doi
pubmed
urn-nbn
Totalt: 294 träffar
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf