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Combined imaging of oxidative stress and microscopic structure reveals new features in human atherosclerotic plaques
Norwegian University of Science and Technoogy, Norway.
Linköpings universitet, Institutionen för medicin och hälsa, Avdelningen för radiologiska vetenskaper. Linköpings universitet, Hälsouniversitetet. Region Östergötland, Diagnostikcentrum, Medicinsk teknik i Östergötland.
Norwegian University of Science and Technoogy, Norway.
Linköpings universitet, Institutionen för medicin och hälsa, Avdelningen för kardiovaskulär medicin. Linköpings universitet, Hälsouniversitetet. Region Östergötland, Hjärt- och Medicincentrum, Fysiologiska kliniken US.
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2015 (engelsk)Inngår i: Journal of Biomedical Optics, ISSN 1083-3668, E-ISSN 1560-2281, Vol. 20, nr 2, s. 020503-Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Human atherosclerotic samples collected by carotid endarterectomy were investigated using electronic paramagnetic resonance imaging (EPRI) for visualization of reactive oxygen species, and nonlinear optical microscopy (NLOM) to study structural features. Regions of strong EPRI signal, indicating a higher concentration of reactive oxygen species and increased inflammation, were found to colocalize with regions dense in cholesterol crystals as revealed by NLOM.

sted, utgiver, år, opplag, sider
Society of Photo-optical Instrumentation Engineers (SPIE) , 2015. Vol. 20, nr 2, s. 020503-
Emneord [en]
atherosclerosis; electronic paramagnetic resonance imaging; polarimetry; nonlinear optical microscopy
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Identifikatorer
URN: urn:nbn:se:liu:diva-116839DOI: 10.1117/1.JBO.20.2.020503ISI: 000350462900003PubMedID: 25714991OAI: oai:DiVA.org:liu-116839DiVA, id: diva2:800634
Merknad

Funding Agencies|Swedish Research Council [diarienr 2009-5430]

Tilgjengelig fra: 2015-04-07 Laget: 2015-04-07 Sist oppdatert: 2019-10-14

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Gustafsson, HåkanZachrisson, HeleneHallbeck, MartinLindgren, Mikael

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