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Glucose, insulin, and the insulin-like growth factor binding protein 1 in the circulation of pregnant women in relation to their own body composition and to that of their infants
Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för kliniska vetenskaper. Linköpings universitet, Hälsouniversitetet.ORCID-id: 0000-0003-2482-7048
Department of Biosciences and Nutrition, Karolinska Institute, NOVUM, Huddinge, Sweden.
Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för kliniska vetenskaper. Linköpings universitet, Hälsouniversitetet.
2015 (engelsk)Manuskript (preprint) (Annet vitenskapelig)
Abstract [en]

Aim: Intrauterine factors influence infant size and body composition but the mechanisms involved are incompletely known. We studied relationships between the body composition of pregnant women and variables related to their glucose homeostasis, i.e. glucose, insulin, HOMA-IR (homeostasis model assessment-insulin resistance), haemoglobin A1c and IGFBP-1 (insulin-like growth factor binding protein 1), in their circulation and related these variables to the body composition of their infants.

Methods: Body composition of 209 women in gestational week 32 and of their healthy, singleton and full-term one-week-old infants was measured using air displacement plethysmography. Glucose homeostasis variables were assessed in gestational week 32.

Results: Insulin/HOMA-IR were positively related to body mass index, fat mass index and fat mass (r2=0.32-0.36, P<0.001) of the women. Their glucose, insulin and HOMA-IR values were positively (P≤0.009) associated, while IGFBP-1was negatively (P=0.001) associated, with infant fat mass. Insulin and HOMA-IR were positively associated with fat mass of daughters (P<0.001), but not of sons (P≥0.65) (Sex-interaction: P≤ 0.042).

Conclusion: Glucose homeostasis variables of pregnant women are related to their own body composition and to that of their infants. The results suggested that a previously identified relationship between fat mass of mothers and daughters is mediated by insulin resistance.

sted, utgiver, år, opplag, sider
2015.
Emneord [en]
Body composition, infant, insulin resistance, mother, sex difference
HSV kategori
Identifikatorer
URN: urn:nbn:se:liu:diva-117431OAI: oai:DiVA.org:liu-117431DiVA, id: diva2:808091
Tilgjengelig fra: 2015-04-27 Laget: 2015-04-27 Sist oppdatert: 2019-06-28bibliografisk kontrollert
Inngår i avhandling
1. Body composition of parents and their infants: methodological, anthropometric, metabolic and genetic studies
Åpne denne publikasjonen i ny fane eller vindu >>Body composition of parents and their infants: methodological, anthropometric, metabolic and genetic studies
2015 (engelsk)Doktoravhandling, med artikler (Annet vitenskapelig)
Abstract [en]

Body composition in infancy may be of importance for later health. In particular, infant body composition may be relevant regarding obesity risk in childhood. Recent advances in body composition methodology using air displacement plethysmography (ADP) have provided possibilities to accurately measure body composition of infants in a quick and non-invasive manner. The aims of this thesis were to study associations of parental body composition using ADP, glucose homeostasis during pregnancy and infant genetics with infant body composition also using ADP. When using ADP in adults, a correction for the thoracic gas volume (TGV) is needed and TGV can be predicted using equations developed in nonpregnant adults. Thus another aim was to study the validity of using such equations during pregnancy.

Parent couples were invited to this study at a routine visit to a maternity clinic in Linköping between September 2008 and October 2010. When the mother was in gestational week 32, parental body composition using ADP and maternal glucose homeostasis variables were assessed. Size and body composition of healthy, singleton and full term (≥ 37 gestational weeks) infants were measured at 1 and 12 weeks of age and a total of 211 infants  were included in the studies. Weight and length at 1 year of age were reported by parents. Saliva samples were collected from the infants to obtain DNA for genotyping of the fat mass and obesity associated (FTO) gene.

Body composition results calculated using measured and predicted TGV were compared in 27 women. Results showed that predicted TGV yields a very marginal overestimation (0.5 %) of fat mass (FM). Further, each kg increase in maternal and paternal fat-free mass (FFM) was associated with 15.6 g (P=0.001) and 9.1 g (P=0.007), respectively, more FFM in their 1-week old infants. FM of fathers was not related to infant FM. However, maternal FM was positively associated with FM of daughters (5.8 g/kg, P=0.007), but not of sons (P=0.79) at 1 week of age. Similarly, each standard deviation increase in maternal HOMA-IR (homeostatic model assessment-insulin resistance) was related to 52.7 more g of FM (P<0.001) in 1-weekold daughters, but no such relationship was found for sons (P=0.79). The number of risk alleles at the FTO locus rs9939609 was not associated with infant body mass index (BMI) or infant FM at 1 or 12 weeks of age. However, the number of risk alleles was positively associated (P≤0.033) with infant length at 1 and 12 weeks of age, and the results suggested that this association was stronger in boys than in girls.

The results presented in this thesis show that: i) The use of predicted TGV when applying ADP in gestational week 32 overestimated % FM only slightly. ii) Associations between parental and infant body composition are present early in life. Thus, parental FFM was positively related to FFM in 1-week-old infants. Furthermore, maternal FM and insulin resistance (HOMA-IR) were positively related to FM of 1-week-old daughters, but no such relationships were observed for sons. iii) The FTO genotype is not associated with infant body fatness at 1 or 12 weeks of age. However, the results suggested that the number of FTO risk alleles is positively associated with infant length, especially in boys.

In conclusion, parental and genetic factors were associated with infant size and body composition and these relationships may be of importance for future body composition and health.

sted, utgiver, år, opplag, sider
Linköping: Linköping University Electronic Press, 2015. s. 67
Serie
Linköping University Medical Dissertations, ISSN 0345-0082 ; 1456
HSV kategori
Identifikatorer
urn:nbn:se:liu:diva-117435 (URN)10.3384/diss.diva-117435 (DOI)978-91-7519-094-5 (ISBN)
Disputas
2015-06-02, Berzeliussalen, Campus US, Linköping, 13:00 (engelsk)
Opponent
Veileder
Forskningsfinansiär
Swedish Research Council, 15402Swedish Research Council Formas, 222-2006-614, 222-2008-1332Magnus Bergvall FoundationSwedish Society of MedicineÖstergötland County Council
Tilgjengelig fra: 2015-04-27 Laget: 2015-04-27 Sist oppdatert: 2019-11-15bibliografisk kontrollert

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