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Is aortic wall shear stress affected by aging? An image-based numerical study with two age groups
Linköpings universitet, Institutionen för medicin och hälsa, Avdelningen för kardiovaskulär medicin. Linköpings universitet, Tekniska fakulteten. Swedish E Science Research Centre SeRC, Sweden.ORCID-id: 0000-0003-1942-7699
Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Mekanisk värmeteori och strömningslära. Linköpings universitet, Tekniska fakulteten. Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV.
Linköpings universitet, Institutionen för medicin och hälsa, Avdelningen för kardiovaskulär medicin. Linköpings universitet, Medicinska fakulteten. Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV. Östergötlands Läns Landsting, Hjärt- och Medicincentrum, Thorax-kärlkliniken i Östergötland.ORCID-id: 0000-0002-9095-403X
Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Mekanisk värmeteori och strömningslära. Linköpings universitet, Tekniska fakulteten. Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV.ORCID-id: 0000-0001-5526-2399
2015 (engelsk)Inngår i: Medical Engineering and Physics, ISSN 1350-4533, E-ISSN 1873-4030, Vol. 37, nr 3, s. 265-271Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

The size of the larger arteries increases during the entire life, but not much is known about how the change in size affects the blood flow. This study compares the flow field in a group of young males (N = 10, age = 23.5 +/- 1.4), with a group of older males (N = 8, age = 58.0 +/- 2.8). Aortic geometries were obtained by magnetic resonance imaging, and the aortic blood flow field was computed using computational fluid dynamics. The aortic wall shear stress was obtained from the computations, and it was concluded that time-averaged wall shear stress decreased with increased age, probably as a consequence of increased aortic diameter and decreased stroke volume, which in turn reduces the shear rates in the aorta. However, the oscillatory shear index, which is a measure of the oscillatory nature of the wall shear stress vector, seemed to be unaffected by aging.

sted, utgiver, år, opplag, sider
Elsevier , 2015. Vol. 37, nr 3, s. 265-271
Emneord [en]
Aorta; Wall shear stress; Oscillatory shear index; Computational fluid dynamics; Aging; Magnetic resonance imaging
HSV kategori
Identifikatorer
URN: urn:nbn:se:liu:diva-117663DOI: 10.1016/j.medengphy.2014.12.011ISI: 000352249800002PubMedID: 25630809OAI: oai:DiVA.org:liu-117663DiVA, id: diva2:811427
Merknad

Funding Agencies|Swedish e-Science Research Centre; Centre for Industrial Information Technology [99.11]; Swedish Research Council [2010-4282]; Swedish Heart and Lung Foundation

Tilgjengelig fra: 2015-05-12 Laget: 2015-05-06 Sist oppdatert: 2017-12-04

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