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Cutaneous malignant melanoma in the Swedish organ transplantation cohort: A study of clinicopathological characteristics and mortality
Karolinska University of Labs, Sweden; Karolinska University, Sweden.
Region Östergötland, Diagnostikcentrum, Klinisk patologi och klinisk genetik. Linköpings universitet, Institutionen för klinisk och experimentell medicin. Linköpings universitet, Medicinska fakulteten.
Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för kliniska vetenskaper. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Centrum för hälso- och vårdutveckling, Regionalt cancercentrum.
Karolinska University Hospital, Sweden.
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2015 (Engelska)Ingår i: The Journal of American Academy of Dermatology, ISSN 0190-9622, E-ISSN 1097-6787, Vol. 73, nr 1, s. 106-U190Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Background: Risk of cutaneous melanoma is increased among organ transplant recipients (OTRs) but outcome has rarely been evaluated. Objective: We sought to assess melanoma characteristics and prognosis among OTRs versus the general population. Methods: Using Swedish health care registers, we identified melanomas in OTRs (n = 49) and in the general population (n = 22,496), given a diagnosis between 1984 and 2008 and followed up through December 31, 2012. Tumor slides of posttransplantation melanomas were reviewed. Odds ratios for comparison of histopathological characteristics and hazard ratios of melanoma-specific death were calculated. Results: Among OTRs the trunk was the most common anatomic melanoma site (50% among female vs 51% among male) and 73% (n = 36) of all melanomas were histologically associated with a melanocytic nevus, 63% (n = 31) atypical/dysplastic. Compared with population melanomas, posttransplantation melanomas were more advanced at diagnosis (Clark level III-V: odds ratio 2.2 [95% confidence interval 1.01-4.7, P = .03], clinical stages III-IV: odds ratio 4.2 [1.6-10.8, P = .003]). Risk of melanoma-specific death was increased among OTRs: adjusted hazard ratio 3.0 (1.7-5.3, P = .0002). Limitations: Only posttransplantation melanoma slides were reviewed. Conclusions: Melanomas were more advanced at diagnosis and melanoma-specific survival was poorer in OTRs than in the general population. Prophylactic excision of truncal nevi among OTRs may be advised.

Ort, förlag, år, upplaga, sidor
Elsevier , 2015. Vol. 73, nr 1, s. 106-U190
Nyckelord [en]
histopathology; immunosuppression; melanocytic nevi; melanoma; melanoma-specific mortality; population-based study; posttransplantation; Swedish Melanoma Register
Nationell ämneskategori
Klinisk medicin
Identifikatorer
URN: urn:nbn:se:liu:diva-120038DOI: 10.1016/j.jaad.2015.03.045ISI: 000356314100031PubMedID: 25929720OAI: oai:DiVA.org:liu-120038DiVA, id: diva2:840021
Anmärkning

Funding Agencies|Welander Foundation; Westerberg Foundation; Strategic Research Program in Epidemiology at Karolinska Institutet, Stockholm, Sweden

Tillgänglig från: 2015-07-06 Skapad: 2015-07-06 Senast uppdaterad: 2017-12-04

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Lyth, Johan

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Klinisk patologi och klinisk genetikInstitutionen för klinisk och experimentell medicinMedicinska fakultetenAvdelningen för kliniska vetenskaperRegionalt cancercentrum
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