liu.seSök publikationer i DiVA
Ändra sökning
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Prognostic significance of high hyperdiploid and triploid/tetraploid adult acute myeloid leukemia
Skåne University Hospital, Sweden; Lund University, Sweden.
Skåne University Hospital, Sweden.
Skåne University Hospital, Sweden; Lund University, Sweden.
Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för kliniska vetenskaper. Region Östergötland, Centrum för kirurgi, ortopedi och cancervård, Hematologiska kliniken US. Linköpings universitet, Medicinska fakulteten.
Visa övriga samt affilieringar
2015 (Engelska)Ingår i: American Journal of Hematology, ISSN 0361-8609, E-ISSN 1096-8652, Vol. 90, nr 9, s. 800-805Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

To ascertain the clinical implications of high hyperdiploid (HH; 49-65 chromosomes) and triploid/tetraploid (TT; greater than65 chromosomes) adult acute myeloid leukemia (AML), all such cases were retrieved from the Swedish AML Registry. Of the 3,654 cytogenetically informative cases diagnosed between January 1997 and May 2014, 68 (1.9%) were HH (n=50)/TT (n=18). Patients with HH/TT were older than those with intermediate risk (IR) AML (median 71 years vs. 67 years; P=0.042) and less often had de novo AML (63% vs. 79%; P=0.004); no such differences were observed between HH/TT and complex karyotype (CK) AML. The overall survival (OS) was similar between patients with HH/TT and CK AML (median 0.9 years vs. 0.6 years; P=0.082), whereas OS was significantly longer (median 1.6 years; P=0.028) for IR AML. The OS was shorter for cases with HH than with TT (median 0.6 years vs. 1.4 years; P=0.032) and for HH/TT AMLs with adverse abnormalities (median 0.8 years vs. 1.1 years; P=0.044). In conclusion, HH/TT AML is associated with a poor outcome, but chromosome numbers greater than65 and absence of adverse aberrations seem to translate into a more favorable prognosis. Thus, HH/TT AMLs are clinically heterogeneous and should not automatically be grouped as high risk.Am. J. Hematol. 90:800-805, 2015. (c) 2015 Wiley Periodicals, Inc.

Ort, förlag, år, upplaga, sidor
WILEY-BLACKWELL , 2015. Vol. 90, nr 9, s. 800-805
Nationell ämneskategori
Hematologi
Identifikatorer
URN: urn:nbn:se:liu:diva-121425DOI: 10.1002/ajh.24091ISI: 000360218000023PubMedID: 26088289OAI: oai:DiVA.org:liu-121425DiVA, id: diva2:855143
Anmärkning

Funding Agencies|Swedish Cancer Society; Swedish Research Council; Regional Cancer Centers; Swedish Association of Local Authorities and Regions (SKL); Governmental Funding of Clinical Research within the National Health Service

Tillgänglig från: 2015-09-18 Skapad: 2015-09-18 Senast uppdaterad: 2017-12-04

Open Access i DiVA

Fulltext saknas i DiVA

Övriga länkar

Förlagets fulltextPubMed

Personposter BETA

Antunovic, Petar

Sök vidare i DiVA

Av författaren/redaktören
Antunovic, Petar
Av organisationen
Avdelningen för kliniska vetenskaperHematologiska kliniken USMedicinska fakulteten
I samma tidskrift
American Journal of Hematology
Hematologi

Sök vidare utanför DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetricpoäng

doi
pubmed
urn-nbn
Totalt: 106 träffar
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf