liu.seSearch for publications in DiVA
Endre søk
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Asymptomatic Helminth Infection in Active Tuberculosis Is Associated with Increased Regulatory and Th-2 Responses and a Lower Sputum Smear Positivity
Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för mikrobiologi och molekylär medicin. Linköpings universitet, Medicinska fakulteten. University of Gondar, Ethiopia.
University of Addis Ababa, Ethiopia.
Vastervik Hospital, Sweden.
University of Gondar, Ethiopia.
Vise andre og tillknytning
2015 (engelsk)Inngår i: PLoS Neglected Tropical Diseases, ISSN 1935-2727, E-ISSN 1935-2735, Vol. 9, nr 8, artikkel-id e0003994Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Background The impact of intestinal helminth infection on the clinical presentation and immune response during active tuberculosis (TB) infection is not well characterized. Our aim was to investigate whether asymptomatic intestinal helminth infection alters the clinical signs and symptoms as well as the cell mediated immune responses in patients with active TB.

Methodology Consecutive, newly diagnosed TB patients and healthy community controls (CCs) were recruited in North-west Ethiopia. TB-score, body mass index and stool samples were analyzed. Cells from HIV-negative TB patients (HIV-/TB) and from CCs were analyzed for regulatory T-cells (Tregs) and cytokine responses using flow cytometry and ELISPOT, respectively.

Results A significantly higher ratio of helminth co-infection was observed in TB patients without HIV (Helm+/HIV-/TB) compared to HIV negative CCs, (40% (121/306) versus 28% (85/306), p = 0.003). Helm+/HIV-/TB patients showed significantly increased IL-5 secreting cells compared to Helm-/HIV-/TB (37 SFU (IQR:13-103) versus 2 SFU (1-50); p = 0.02, n = 30). Likewise, levels of absolute Tregs (9.4 (3.2-16.7) cells/mu l versus 2.4 (1.1-4.0) cells/mu l; p = 0.041) and IL-10 secreting cells (65 SFU (7-196) versus 1 SFU (0-31); p = 0.014) were significantly higher in Helm+/HIV-/TB patients compared to Helm-/HIV-/TB patients. In a multivariate analysis, a lower rate of sputum smear positivity for acid fast bacilli, lower body temperature, and eosinophilia were independently associated with helminth infection in TB patients.

Conclusions Asymptomatic helminth infection is associated with increased regulatory T-cell and Th2-type responses and a lower rate of sputum smear positivity. Further studies are warranted to investigate the clinical and immunological impact of helminth infection in TB patients.

sted, utgiver, år, opplag, sider
PUBLIC LIBRARY SCIENCE , 2015. Vol. 9, nr 8, artikkel-id e0003994
HSV kategori
Identifikatorer
URN: urn:nbn:se:liu:diva-121763DOI: 10.1371/journal.pntd.0003994ISI: 000360708200058PubMedID: 26248316OAI: oai:DiVA.org:liu-121763DiVA, id: diva2:859348
Merknad

Funding Agencies|SAREC/SIDA; EU/EDCTP [JP 10800.006]; Swedish Research Council; Swedish Heart and Lung Foundation (Oscar II Jubilee Foundation); Wallenberg Foundation; Armauer Hansen Research Institute

Tilgjengelig fra: 2015-10-06 Laget: 2015-10-05 Sist oppdatert: 2018-01-11

Open Access i DiVA

fulltext(638 kB)258 nedlastinger
Filinformasjon
Fil FULLTEXT01.pdfFilstørrelse 638 kBChecksum SHA-512
9ec05d51f969e3ee00e68092e5fdc6291c14d21b49264358a5997a19908173a6ec871d3bc4ea37c03410950e051649dd579091e6aed2f1981301f86549f1bf25
Type fulltextMimetype application/pdf

Andre lenker

Forlagets fulltekstPubMed

Personposter BETA

Abate, EbbaStendahl, OlleSchön, Thomas

Søk i DiVA

Av forfatter/redaktør
Abate, EbbaStendahl, OlleSchön, Thomas
Av organisasjonen
I samme tidsskrift
PLoS Neglected Tropical Diseases

Søk utenfor DiVA

GoogleGoogle Scholar
Totalt: 258 nedlastinger
Antall nedlastinger er summen av alle nedlastinger av alle fulltekster. Det kan for eksempel være tidligere versjoner som er ikke lenger tilgjengelige

doi
pubmed
urn-nbn

Altmetric

doi
pubmed
urn-nbn
Totalt: 1368 treff
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf