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Health-Related Quality of Life In Patients With Adrenal Insufficiency Receiving Plenadren Compared With Immediate-Release Hydrocortisone.
Sahlgrenska University Hospital, Gothenburg, Sweden.
Sahlgrenska University Hospital, Gothenburg, Sweden.
Shire, Danderyd, Sweden.
Östergötlands Läns Landsting, Hjärt- och Medicincentrum, Endokrinmedicinska kliniken. Linköpings universitet, Institutionen för medicin och hälsa, Avdelningen för kardiovaskulär medicin. Linköpings universitet, Medicinska fakulteten.
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2015 (Engelska)Ingår i: Value in Health, ISSN 1098-3015, E-ISSN 1524-4733, Vol. 18, nr 7, s. A616-Artikel i tidskrift, Meeting abstract (Refereegranskat) Published
Abstract [en]

Background

Previous studies in patients with primary adrenal insufficiency (PAI) on conventional replacement therapy suggest decreased health-related quality of life (HRQoL), and that patients report more frequently fatigue, increased anxiety and inability to work compared to background population.

Objectives

To study self-reported health status with EQ-5D in patients with PAI. Patients treated with Plenadren (modified-release hydrocortisone) were compared with patients treated with immediate release hydrocortisone (IRHC) replacement therapy.

Methods

This was a cross-sectional, multi-centre, non-interventional survey of patients with PAI receiving Plenadren or immediate release hydrocortisone (IRHC) replacement.

Subjects

One hundred thirty-four adult patients with PAI of whom 36 (19 females [53%]) were treated with Plenadren and 98 (77 females [79%]) were treated with IRHC, were included.

MAIN OUTCOME MEASURE

HRQoL described by the EQ-5D, a generic preference-based measure of health.

RESULTS

Patients on Plenadren and on IRHC had a mean ± SD age of 53.1 ± 12.7 years and 48.0 ± 13.1 years, respectively (P=0.043). The majority of the patients were diagnosed more than 5 years ago (69%). The mean ± SD daily Plenadren and IRHC doses were 27.0 ± 6.8 mg and 26.6 ± 10.9 mg, respectively (P=0.807). 47% of the Plenadren patients had been receiving Plenadren and 82% of the IRHC patients had been receiving IRHC for more than 3 years. Patients receiving Plenadren had better HRQoL measured by the EQ-5D questionnaire compared to patients replaced with IRHC (0.76 ± 0.18 vs 0.68 ± 0.18, respectively [P=0.040]).

CONCLUSIONS

Replacement therapy with Plenadren in patients with PAI confers measurable benefit on HRQoL relative to IRHC as estimated by the EQ-5D questionnaire, and may therefore be advantageous when compared to IRHC substitution.

Ort, förlag, år, upplaga, sidor
2015. Vol. 18, nr 7, s. A616-
Nationell ämneskategori
Hälso- och sjukvårdsorganisation, hälsopolitik och hälsoekonomi Kirurgi
Identifikatorer
URN: urn:nbn:se:liu:diva-124656DOI: 10.1016/j.jval.2015.09.2145PubMedID: 26533455OAI: oai:DiVA.org:liu-124656DiVA, id: diva2:901830
Tillgänglig från: 2016-02-09 Skapad: 2016-02-08 Senast uppdaterad: 2017-11-30

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Ekman, BertilWahlberg, Jeanette

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Value in Health
Hälso- och sjukvårdsorganisation, hälsopolitik och hälsoekonomiKirurgi

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