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Coloured cornea replacements with anti-infective properties: expanding the safe use of silver nanoparticles in regenerative medicine.
Bio-nanomaterials Chemistry and Engineering Laboratory, Division of Cardiac Surgery, University of Ottawa Heart Institute, 40 Ruskin Street, Rm H5229, Ottawa, Canada.
Bio-nanomaterials Chemistry and Engineering Laboratory, Division of Cardiac Surgery, University of Ottawa Heart Institute, 40 Ruskin Street, Rm H5229, Ottawa, Canada.
Bio-nanomaterials Chemistry and Engineering Laboratory, Division of Cardiac Surgery, University of Ottawa Heart Institute, 40 Ruskin Street, Rm H5229, Ottawa, Canada.
Bio-nanomaterials Chemistry and Engineering Laboratory, Division of Cardiac Surgery, University of Ottawa Heart Institute, 40 Ruskin Street, Rm H5229, Ottawa, Canada.
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2016 (Engelska)Ingår i: Nanoscale, ISSN 2040-3364, E-ISSN 2040-3372, Vol. 8, nr 12, s. 6484-6489Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Despite the broad anti-microbial and anti-inflammatory properties of silver nanoparticles (AgNPs), their use in bioengineered corneal replacements or bandage contact lenses has been hindered due to their intense yellow coloration. In this communication, we report the development of a new strategy to pre-stabilize and incorporate AgNPs with different colours into collagen matrices for fabrication of corneal implants and lenses, and assessed their in vitro and in vivo activity.

Ort, förlag, år, upplaga, sidor
Royal Society of Chemistry, 2016. Vol. 8, nr 12, s. 6484-6489
Nationell ämneskategori
Biomaterialvetenskap
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URN: urn:nbn:se:liu:diva-126612DOI: 10.1039/c6nr01339bISI: 000372851500033PubMedID: 26949000OAI: oai:DiVA.org:liu-126612DiVA, id: diva2:915892
Anmärkning

Funding agencies: Natural Sciences and Engineering Research Council [342107, RGPIN-2015-06325]; Swedish Research Council [521-2012-5706, 621-2012-4286]; University of Ottawa; Alexander Graham Bell/Canada Graduate (CGS-M/NSERC) Scholarship; Ontario Graduate Scholarships (OG

Tillgänglig från: 2016-03-31 Skapad: 2016-03-31 Senast uppdaterad: 2017-11-30Bibliografiskt granskad

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