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Noise Alters Hair-Bundle Mechanics at the Cochlear Apex
Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för cellbiologi. Linköpings universitet, Medicinska fakulteten.
Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för cellbiologi. Linköpings universitet, Medicinska fakulteten.
2015 (engelsk)Inngår i: Mechanics of hearing: Protein to perception, American Institute of Physics (AIP), 2015, Vol. 1703, nr 030014, s. 030014-1-030014-5Konferansepaper, Publicerat paper (Fagfellevurdert)
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Abstract [en]

Exposure to loud sounds can lead to both permanent and short term changes in auditory sensitivity. Permanent hearing loss is often associated with gross changes in cochlear morphology including the loss of hair cells and auditory nerve fibers while the mechanisms of short term threshold shifts are much less well understood and may vary at different locations across the cochlea. Previous reports suggest that exposure to loud sounds leads to a decrease in the cochlear microphonic potential and in the stiffness of the organ of Corti. Because the cochlear microphonic reflects changes in the membrane potential of the hair cells, this suggests that hair-bundle motion should be reversibly altered following exposure to loud sounds. Using an in vitro preparation of the guinea pig temporal bone we investigate changes in the micro-mechanical response near the cochlear apex following a brief (up to 10 - 20 minutes) exposure to loud (similar to 120 dB) tones near the best frequency at this location. We use time-resolved confocal imaging to record the motion of outer hair cell bundles before and after acoustic overstimulation. We have also recorded larger-scale structural views of the organ of Corti before and after exposure to the loud sound. Conventional electrophysiological techniques are used measure the cochlear microphonic potential. As has been previously reported, following acoustic overexposure the cochlear microphonic declines in value and typically recovers on the order of 30 - 60 minutes. Hair-bundle trajectories are affected following the loud sound and typically recover on a somewhat faster time scale than the microphonic potential, although the results vary considerably across preparations. Preliminary results also suggest reversible changes in the hair cells resting potential following the loud sound.

sted, utgiver, år, opplag, sider
American Institute of Physics (AIP), 2015. Vol. 1703, nr 030014, s. 030014-1-030014-5
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AIP Conference Proceedings, ISSN 0094-243X
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URN: urn:nbn:se:liu:diva-127079DOI: 10.1063/1.4939329ISI: 000372065400016ISBN: 978-0-7354-1350-4 (tryckt)OAI: oai:DiVA.org:liu-127079DiVA, id: diva2:919315
Konferanse
12th International Workshop on the Mechanics of Hearing, Cape Sounio, Greece, 23–29 June 2014
Tilgjengelig fra: 2016-04-13 Laget: 2016-04-13 Sist oppdatert: 2016-04-28

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