liu.seSök publikationer i DiVA
Ändra sökning
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
St Gallen molecular subtypes in screening-detected and symptomatic breast cancer in a prospective cohort with long-term follow-up
Clin Science Lund, Sweden; Hospital Helsingborg, Sweden.
Lund University, Sweden; Skåne University Hospital, Sweden.
Clin Science Lund, Sweden.
Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för inflammationsmedicin. Linköpings universitet, Hälsouniversitetet. Region Östergötland, Diagnostikcentrum, Klinisk patologi och klinisk genetik.
Visa övriga samt affilieringar
2016 (Engelska)Ingår i: British Journal of Surgery, ISSN 0007-1323, E-ISSN 1365-2168, Vol. 103, nr 5, s. 513-523Artikel i tidskrift (Refereegranskat) Published
Resurstyp
Text
Abstract [en]

Background: Diagnosis by screening mammography is considered an independent positive prognostic factor, although the data are not fully in agreement. The aim of the study was to explore whether the mode of detection (screening-detected versus symptomatic) adds prognostic information to the St Gallen molecular subtypes of primary breast cancer, in terms of 10-year cumulative breast cancer mortality (BCM). Methods: A prospective cohort of patients with primary breast cancer, who had regularly been invited to screening mammography, were included. Tissue microarrays were constructed from primary tumours and lymph node metastases, and evaluated by two independent pathologists. Primary tumours and lymph node metastases were classified into St Gallen molecular subtypes. Cause of death was retrieved from the Central Statistics Office. Results: A total of 434 patients with primary breast cancer were included in the study. Some 370primary tumours and 111 lymph node metastases were classified into St Gallen molecular subtypes. The luminal A-like subtype was more common among the screening-detected primary tumours (P=0.035) and corresponding lymph node metastases (P=0.114) than among symptomatic cancers. Patients with screening-detected tumours had a lower BCM (P=0.017), and for those diagnosed with luminal A-like tumours the 10-year cumulative BCM was 3 per cent. For patients with luminal A-like lymph node metastases, there was no BCM. In a stepwise multivariable analysis, the prognostic information yielded by screening detection was hampered by stage and tumour biology. Conclusion: The prognosis was excellent for patients within the screening programme who were diagnosed with a luminal A-like primary tumour and/or lymph node metastases. Stage, molecular pathology and mode of detection help to define patients at low risk of death from breast cancer.

Ort, förlag, år, upplaga, sidor
WILEY-BLACKWELL , 2016. Vol. 103, nr 5, s. 513-523
Nationell ämneskategori
Klinisk medicin
Identifikatorer
URN: urn:nbn:se:liu:diva-127415DOI: 10.1002/bjs.10070ISI: 000372914100006PubMedID: 26856820OAI: oai:DiVA.org:liu-127415DiVA, id: diva2:925581
Anmärkning

Funding Agencies|Swedish Breast Cancer Organization (BRO); Swedish Cancer Society [2010/1234, 2010/501]; Gunnar Nilsson Cancer Foundation [2013/1224]; Mrs Berta Kamprad Foundation [2014/36]; Skane County Councils Research and Development Foundation [2014/45208]; Governmental Funding of Clinical Research within National Health Service (ALF) [2014/434901]; Gyllenstiernska Krapperup Foundation [2014/1702]; Stig and Ragna Gorthons Stiftelse

Tillgänglig från: 2016-05-02 Skapad: 2016-04-26 Senast uppdaterad: 2017-11-30

Open Access i DiVA

fulltext(319 kB)150 nedladdningar
Filinformation
Filnamn FULLTEXT01.pdfFilstorlek 319 kBChecksumma SHA-512
2b840f1bb9a6b1aa39fb1a733682d702a157d0b09f9c164054ed4287c688b733f141ce92c4c27f1af1e118b348ac4f1e02516842faba43bd4f44aec6fd5bbfa9
Typ fulltextMimetyp application/pdf

Övriga länkar

Förlagets fulltextPubMed

Personposter BETA

Olsson, Hans

Sök vidare i DiVA

Av författaren/redaktören
Olsson, Hans
Av organisationen
Avdelningen för inflammationsmedicinHälsouniversitetetKlinisk patologi och klinisk genetik
I samma tidskrift
British Journal of Surgery
Klinisk medicin

Sök vidare utanför DiVA

GoogleGoogle Scholar
Totalt: 150 nedladdningar
Antalet nedladdningar är summan av nedladdningar för alla fulltexter. Det kan inkludera t.ex tidigare versioner som nu inte längre är tillgängliga.

doi
pubmed
urn-nbn

Altmetricpoäng

doi
pubmed
urn-nbn
Totalt: 230 träffar
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf