liu.seSearch for publications in DiVA
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
3D Corneal Shape After Implantation of a Biosynthetic Corneal Stromal Substitute
Maisonneuve Rosemt Hospital, Canada; University of Montreal, Canada.
University of Montreal, Canada.
Maisonneuve Rosemt Hospital, Canada.
Linköping University, Department of Clinical and Experimental Medicine, Division of Neuro and Inflammation Science. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Department of Ophthalmology in Linköping.ORCID iD: 0000-0003-1079-4361
Show others and affiliations
2016 (English)In: Investigative Ophthalmology and Visual Science, ISSN 0146-0404, E-ISSN 1552-5783, Vol. 57, no 6, p. 2355-2365Article in journal (Refereed) Published
Resource type
Text
Abstract [en]

PURPOSE. The current and projected shortage of transplantable human donor corneas has prompted the development of long-term alternatives to human donor tissue for corneal replacement. The biosynthetic stromal substitutes (BSS) characterized herein represent a potentially safe alternative to donor organ transplantation for anterior corneal stromal diseases. The goal of this phase 1 safety study was to characterize the three-dimensional (3D) corneal shape of the first 10 human patients implanted with a BSS and assess its stability over time. METHODS. Ten patients underwent anterior lamellar keratoplasty using a biosynthetic corneal stromal implant for either advanced keratoconus or central corneal scarring. Surgeries were performed at Linkoping University Hospital, between October and November 2007. Serial corneal topographies were performed on all eyes up to a 4-year follow-up when possible. Three-dimensional shape average maps were constructed for the 10 BSS corneas and for 10 healthy controls. Average 3D shape corneal elevation maps, difference maps, and statistics maps were generated. RESULTS. The biosynthetic stromal substitutes implants remained stably integrated into the host corneas over the 4-year follow-up period, without signs of wound dehiscence or implant extrusion. The biosynthetic stromal substitutes corneas showed steeper surface curvatures and were more irregular than the healthy controls. CONCLUSIONS. Corneal astigmatism and surface steepness were observed 4 years after BSS implantation, while the implants remained stably integrated in the host corneas. Future studies will indicate if biomaterials technology will allow for the optimization of postoperative surface irregularity after anterior stromal replacement, a new window of opportunity that is not available with traditional corneal transplantation techniques.

Place, publisher, year, edition, pages
ASSOC RESEARCH VISION OPHTHALMOLOGY INC , 2016. Vol. 57, no 6, p. 2355-2365
Keywords [en]
corneal implants; artificial cornea; corneal topography; corneal transplantation; keratoconus
National Category
Ophthalmology
Identifiers
URN: urn:nbn:se:liu:diva-130307DOI: 10.1167/iovs.15-18271ISI: 000378041700001PubMedID: 27136462OAI: oai:DiVA.org:liu-130307DiVA, id: diva2:950494
Note

Funding Agencies|Canadian Institutes of Health Research, Canada [MOP 106517]; Stem Cell Network, Ottawa, ON, Canada; FRQS Research in Vision Network, Montreal, QC, Canada; County Council of Ostergotland, Sweden; Charles-Albert Poissant Research Chair in Corneal Transplantation, University of Montreal, Canada

Available from: 2016-07-31 Created: 2016-07-28 Last updated: 2018-01-22

Open Access in DiVA

fulltext(1419 kB)1301 downloads
File information
File name FULLTEXT01.pdfFile size 1419 kBChecksum SHA-512
443e36e4f0a2a4477faa7359e1b49b7dcca2cb512621748754d086e5b6458b8bbee869e93d126ae8de0a1d8d90a25e29d48affb32ee202b40f4fb0cc5ee7930d
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Authority records

Lagali, NeilFagerholm, PerGriffith, May

Search in DiVA

By author/editor
Lagali, NeilFagerholm, PerGriffith, May
By organisation
Division of Neuro and Inflammation ScienceFaculty of Medicine and Health SciencesDepartment of Ophthalmology in LinköpingDivision of Cell Biology
In the same journal
Investigative Ophthalmology and Visual Science
Ophthalmology

Search outside of DiVA

GoogleGoogle Scholar
Total: 1302 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 257 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf