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Can Removal of Middle Molecular Uremic Retention Solutes be Estimated by UV-absorbance Measurements in Spent Dialysate?
Tallinn University of Technology, Estonia.
Tallinn University of Technology, Estonia; North Estonian Medical Centre, Estonia.
Tallinn University of Technology, Estonia.
Tallinn University of Technology, Estonia.
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2015 (English)In: WORLD CONGRESS ON MEDICAL PHYSICS AND BIOMEDICAL ENGINEERING, 2015, VOLS 1 AND 2, Springer, 2015, Vol. 51, 1297-1300 p.Conference paper, Published paper (Refereed)
Abstract [en]

The objectives of this study were: (1) to compare removal of the middle molecular (MM) and small uremic retention solutes; (2) to investigate if MM removal can be assessed by UV-absorbance at the wavelength of 297 nm during various dialysis treatment modalities. Seven uremic patients, four females and three males, mean age 58.1 +/- 8.7 years, were included into the study during 28 chronic hemodialysis sessions. A parameter, reduction ratio (RR) in percentage, was calculated for a small uremic retention solute urea, for a MM retention solute beta2-microglobulin (B2M), and for UV-absorbance at the wavelength of 297 during different dialysis modalities: conventional hemodialysis (HD), high flux hemodialysis (HF-HD), and postdilutional online hemodiafiltration (HDF) with different parameter settings. Achieved results were compared regarding mean values and SD, and by systematic and standard errors (BIAS +/- SE). It was found that RR is similar for small and MM uremic retention solutes in case of dialysis modality with the highest convective transport, HDF (78.9 +/- 8.1% for urea and 78.1 +/- 6.8% for B2M, N=7). Moreover, RR of small uremic retention solutes can be estimated with sufficient accuracy by UV-absorbance at 297 nm in the spent dialysate for all modalities (BIAS +/- SE: 1.7 +/- 4.0%, N=28), and for MM uremic retention solutes only for HDF (BIAS +/- SE: 1.1 +/- 7.1%, N=7). The results should be confirmed by appropriate kinetic modeling in the next studies.

Place, publisher, year, edition, pages
Springer, 2015. Vol. 51, 1297-1300 p.
Series
IFMBE Proceedings, ISSN 1680-0737
Keyword [en]
Middle molecules; uremic toxins; beta2-microglobulin; uremic retention solutes; urea; dialysis; UV-absorbance
National Category
Radiology, Nuclear Medicine and Medical Imaging
Identifiers
URN: urn:nbn:se:liu:diva-131740DOI: 10.1007/978-3-319-19387-8_315ISI: 000381813000315ISBN: 978-3-319-19387-8; 978-3-319-19386-1 (print)OAI: oai:DiVA.org:liu-131740DiVA: diva2:1001336
Conference
World Congress on Medical Physics and Biomedical Engineering
Available from: 2016-09-30 Created: 2016-09-30 Last updated: 2016-09-30

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Uhlin, Fredrik
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Department of Medical and Health SciencesFaculty of Medicine and Health SciencesDepartment of Nephrology
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