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Inter-hemispheric plasticity in patients with median nerve injury
Region Östergötland, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Orthopaedics in Norrköping. Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Department of Anaesthesiology and Intensive Care in Norrköping.
Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Department of Hand and Plastic Surgery. Linköping University, Center for Medical Image Science and Visualization (CMIV). Linköping University, Faculty of Medicine and Health Sciences.
Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
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2016 (English)In: Neuroscience Letters, ISSN 0304-3940, E-ISSN 1872-7972, Vol. 628, 59-66 p.Article in journal (Refereed) Published
Abstract [en]

Peripheral nerve injuries result in reorganization within the contralateral hemisphere. Furthermore, recent animal and human studies have suggested that the plastic changes in response to peripheral nerve injury also include several areas of the ipsilateral hemisphere. The objective of this study was to map the inter-hemispheric plasticity in response to median nerve injury, to investigate normal differences in contra- and ipsilateral activation, and to study the impact of event-related or blocked functional magnetic resonance imaging (fMRI) design on ipsilateral activation. Four patients with median nerve injury at the wrist (injured and epineurally sutured amp;gt;2 years earlier) and ten healthy volunteers were included. 3T fMRI was used to map the hemodynamic response to brain activity during tactile stimulation of the fingers, and a laterality index (LI) was calculated. Stimulation of Digits II-III of the injured hand resulted in a reduction in contralateral activation in the somatosensory area SI. Patients had a lower LI (0.21 +/- 0.15) compared to healthy controls (0.60 +/- 0.26) indicating greater ipsilateral activation of the primary somatosensory cortex. The spatial dispersion of the coordinates for areas SI and SII was larger in the ipsilateral than in the contralateral hemisphere in the healthy controls, and was increased in the contralateral hemisphere of the patients compared to the healthy controls. There was no difference in LI between the event-related and blocked paradigms. In conclusion, patients with median nerve injury have increased ipsilateral SI area activation, and spatially more dispersed contralateral SI activation during tactile stimulation of their injured hand. In normal subjects ipsilateral activation has larger spatial distribution than the contralateral. Previous findings in patients performed with the blocked fMRI paradigm were confirmed. The increase in ipsilateral SI activation may be due to an interhemispheric disinhibition associated with changes in the afferent signal inflow to the contralateral primary somatosensory cortex.

Place, publisher, year, edition, pages
Elsevier, 2016. Vol. 628, 59-66 p.
Keyword [en]
Peripheral nerve injury; Regeneration; Cortical plasticity; fMRI; Median nerve; Human
National Category
Neurology
Identifiers
URN: urn:nbn:se:liu:diva-131686DOI: 10.1016/j.neulet.2016.06.018ISI: 000381590800010PubMedID: 27291455OAI: oai:DiVA.org:liu-131686DiVA: diva2:1014861
Available from: 2016-10-03 Created: 2016-09-30 Last updated: 2017-05-02Bibliographically approved

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Nyman, TorbjörnHansson, ThomasEngström, Maria
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Department of Orthopaedics in NorrköpingDepartment of Anaesthesiology and Intensive Care in NorrköpingDivision of Clinical SciencesDepartment of Hand and Plastic SurgeryCenter for Medical Image Science and Visualization (CMIV)Faculty of Medicine and Health SciencesDivision of Radiological Sciences
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Neuroscience Letters
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