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Cumulative evidence for MS as a neural network disconnection syndrome consistent with cognitive impairment mechanisms and the confounding role of fatigue and depressionoutlook from the Fourth Nordic MS symposium
Linköping University, Department of Medical and Health Sciences, Division of Radiological Sciences. Linköping University, Faculty of Medicine and Health Sciences. Linköping University, Center for Medical Image Science and Visualization (CMIV).ORCID iD: 0000-0003-3587-3568
2016 (English)In: Acta Neurologica Scandinavica, ISSN 0001-6314, E-ISSN 1600-0404, Vol. 134Article, review/survey (Refereed) Published
Abstract [en]

The Fourth Nordic MS symposium served as a platform to present an overview over the rise and impact of cognitive impairment in people with MS, from early stages on, impairing their quality of life. After discussing MS and cognitive impairment symptoms, a review on the pathophysiology underlying cognitive impairment was given, followed by a talk on neuroimaging highlighting cortical reorganization in MS-affected brains. As a conclusion, therapy and treatment options were discussed. The symposium presented several cutting-edge research studies providing or testing working models that appear successful in predicting and explaining cognitive impairment in MS, such as the disconnection syndrome.

Place, publisher, year, edition, pages
WILEY-BLACKWELL , 2016. Vol. 134
Keyword [en]
cognition; cognitive impairment; connectivity; disconnection syndrome; fatigue; multiple sclerosis
National Category
Gerontology, specializing in Medical and Health Sciences
URN: urn:nbn:se:liu:diva-132350DOI: 10.1111/ane.12655ISI: 000383631700002PubMedID: 27580899OAI: diva2:1046194

Funding Agencies|TEVA

Available from: 2016-11-12 Created: 2016-11-01 Last updated: 2016-11-12

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Veenstra, Helene
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Division of Radiological SciencesFaculty of Medicine and Health SciencesCenter for Medical Image Science and Visualization (CMIV)
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Gerontology, specializing in Medical and Health Sciences

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