Psychological Resources Are Independently Associated with Markers of Inflammation in a Middle-Aged Community Sample
2016 (English)In: International Journal of Behavioral Medicine, ISSN 1070-5503, E-ISSN 1532-7558, Vol. 23, no 5, 611-620 p.Article in journal (Refereed) Published
Purpose To elucidate possible independent associations of psychological resources with inflammatory markers, all linked with coronary heart disease (CHD). Method In a middle-aged general population (n = 944), psychological resources (coping, self-esteem, and sense of coherence (SOC)), a global measure of quality of life (Cantrils self-anchoring ladder, also called "ladder of life"), and psychological risk factors (hopelessness, vital exhaustion, and depressive symptoms) were used in linear regression models to evaluate associations with the inflammatory markers interleukin (IL)-6, C-reactive protein (CRP), and matrix metalloproteinase (MMP)-9. Adjustments were done for age, sex, medical conditions, and cardiovascular risk factors. Results After full adjustments, self-esteem was independently associated with all three biomarkers. Ladder of life was associated with IL-6 and log-CRP; coping, vital exhaustion, and depressive symptoms with IL-6; and SOC with MMP-9 (p amp;lt; 0.05 for all associations). Conclusion Numerous significant associations of psychological resources and risk factors with IL-6, CRP, and MMP-9 were found in a community-based sample. The associations of psychological resources were mostly independent, while the psychological risk factors seemed preferentially dependent on lifestyle factors as smoking, physical activity, and body mass index (BMI). This suggests that the psychological resources (in particular self-esteem) protective effects on CHD are linked to inflammatory markers.
Place, publisher, year, edition, pages
SPRINGER , 2016. Vol. 23, no 5, 611-620 p.
Inflammation; Biomarker; Positive psychology, self-anchoring ladder; Psychoneuroimmunology; Epidemiology
Gerontology, specializing in Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-132341DOI: 10.1007/s12529-016-9553-zISI: 000384594900010PubMedID: 26979423OAI: oai:DiVA.org:liu-132341DiVA: diva2:1046205
Funding Agencies|Swedish Research Council [2004-1881]; Swedish Heart and Lung Foundation 2016-11-122016-11-012016-12-02