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Psychological Resources Are Independently Associated with Markers of Inflammation in a Middle-Aged Community Sample
Linköping University, Department of Clinical and Experimental Medicine, Division of Neuro and Inflammation Science. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Local Health Care Services in Central Östergötland, Department of Psychiatry.
Linköping University, Department of Clinical and Experimental Medicine, Division of Neuro and Inflammation Science. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Diagnostics, Department of Clinical Immunology and Transfusion Medicine.
Linköping University, Department of Medical and Health Sciences, Division of Cardiovascular Medicine. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Heart and Medicine Center, Department of Cardiology in Linköping.
Linköping University, Department of Medical and Health Sciences, Division of Community Medicine. Linköping University, Faculty of Medicine and Health Sciences.
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2016 (English)In: International Journal of Behavioral Medicine, ISSN 1070-5503, E-ISSN 1532-7558, Vol. 23, no 5, 611-620 p.Article in journal (Refereed) Published
Abstract [en]

Purpose To elucidate possible independent associations of psychological resources with inflammatory markers, all linked with coronary heart disease (CHD). Method In a middle-aged general population (n = 944), psychological resources (coping, self-esteem, and sense of coherence (SOC)), a global measure of quality of life (Cantrils self-anchoring ladder, also called "ladder of life"), and psychological risk factors (hopelessness, vital exhaustion, and depressive symptoms) were used in linear regression models to evaluate associations with the inflammatory markers interleukin (IL)-6, C-reactive protein (CRP), and matrix metalloproteinase (MMP)-9. Adjustments were done for age, sex, medical conditions, and cardiovascular risk factors. Results After full adjustments, self-esteem was independently associated with all three biomarkers. Ladder of life was associated with IL-6 and log-CRP; coping, vital exhaustion, and depressive symptoms with IL-6; and SOC with MMP-9 (p amp;lt; 0.05 for all associations). Conclusion Numerous significant associations of psychological resources and risk factors with IL-6, CRP, and MMP-9 were found in a community-based sample. The associations of psychological resources were mostly independent, while the psychological risk factors seemed preferentially dependent on lifestyle factors as smoking, physical activity, and body mass index (BMI). This suggests that the psychological resources (in particular self-esteem) protective effects on CHD are linked to inflammatory markers.

Place, publisher, year, edition, pages
SPRINGER , 2016. Vol. 23, no 5, 611-620 p.
Keyword [en]
Inflammation; Biomarker; Positive psychology, self-anchoring ladder; Psychoneuroimmunology; Epidemiology
National Category
Gerontology, specializing in Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-132341DOI: 10.1007/s12529-016-9553-zISI: 000384594900010PubMedID: 26979423OAI: oai:DiVA.org:liu-132341DiVA: diva2:1046205
Note

Funding Agencies|Swedish Research Council [2004-1881]; Swedish Heart and Lung Foundation [2004053]

Available from: 2016-11-12 Created: 2016-11-01 Last updated: 2016-12-02

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Marteinsdottir, InaErnerudh, JanJonasson, LenaKristenson, MargaretaGarvin, Peter
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Division of Neuro and Inflammation ScienceFaculty of Medicine and Health SciencesDepartment of PsychiatryDepartment of Clinical Immunology and Transfusion MedicineDivision of Cardiovascular MedicineDepartment of Cardiology in LinköpingDivision of Community MedicineDepartment of Medical and Health SciencesResearch & Development Unit in Local Health Care
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International Journal of Behavioral Medicine
Gerontology, specializing in Medical and Health Sciences

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