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ProQ3: Improved model quality assessments using Rosetta energy terms
Stockholm University, Sweden.
Stockholm University, Sweden; Science Life Lab, Sweden.
Linköping University, Department of Physics, Chemistry and Biology, Bioinformatics. Linköping University, Faculty of Science & Engineering.ORCID iD: 0000-0002-3772-8279
Stockholm University, Sweden.
2016 (English)In: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 6, 33509Article in journal (Refereed) Published
Abstract [en]

Quality assessment of protein models using no other information than the structure of the model itself has been shown to be useful for structure prediction. Here, we introduce two novel methods, ProQRosFA and ProQRosCen, inspired by the state-of-art method ProQ2, but using a completely different description of a protein model. ProQ2 uses contacts and other features calculated from a model, while the new predictors are based on Rosetta energies: ProQRosFA uses the full-atom energy function that takes into account all atoms, while ProQRosCen uses the coarse-grained centroid energy function. The two new predictors also include residue conservation and terms corresponding to the agreement of a model with predicted secondary structure and surface area, as in ProQ2. We show that the performance of these predictors is on par with ProQ2 and significantly better than all other model quality assessment programs. Furthermore, we show that combining the input features from all three predictors, the resulting predictor ProQ3 performs better than any of the individual methods. ProQ3, ProQRosFA and ProQRosCen are freely available both as a webserver and stand-alone programs at http://proq3.bioinfo.se/.

Place, publisher, year, edition, pages
NATURE PUBLISHING GROUP , 2016. Vol. 6, 33509
National Category
Bioinformatics (Computational Biology)
Identifiers
URN: urn:nbn:se:liu:diva-132335DOI: 10.1038/srep33509ISI: 000384595800001PubMedID: 27698390OAI: oai:DiVA.org:liu-132335DiVA: diva2:1046207
Note

Funding Agencies|Swedish Research Council [VR-NT 2012-5046, 2012-5270]; Swedish e-Science Research Center (SeRC); Bioinformatics Infrastructure for Life Science (BILS)

Available from: 2016-11-12 Created: 2016-11-01 Last updated: 2016-12-02

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Wallner, Björn
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