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Identification of Stage-Specific Surface Markers in Early B Cell Development Provides Novel Tools for Identification of Progenitor Populations
Lund University, Sweden.
Lund University, Sweden.
Linköping University, Department of Clinical and Experimental Medicine, Division of Microbiology and Molecular Medicine. Linköping University, Faculty of Medicine and Health Sciences.
Lund University, Sweden.
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2016 (English)In: Journal of Immunology, ISSN 0022-1767, E-ISSN 1550-6606, Vol. 197, no 5, 1937-1944 p.Article in journal (Refereed) Published
Abstract [en]

Whereas the characterization of B lymphoid progenitors has been facilitated by the identification of lineage- nd stage-specific surface markers, the continued identification of differentially expressed proteins increases our capacity to explore normal and malignant B cell development. To identify novel surface markers with stage-specific expression patterns, we explored the reactivity of CD19(+) B cell progenitor cells to Abs targeted to 176 surface proteins. Markers with stage-specific expression were identified using a transgenic reporter gene system subdividing the B cell progenitors into four surface IgM(-) stages. This approach affirmed the utility of known stage-specific markers, as well as identifying additional proteins that selectively marked defined stages of B cell development. Among the stage-specific markers were the cell adhesion proteins CD49E, CD11A, and CD54 that are highly expressed selectively on the most immature progenitors. This work identifies a set of novel stage-specific surface markers that can be used as a complement to the classical staining protocols to explore B lymphocyte development.

Place, publisher, year, edition, pages
AMER ASSOC IMMUNOLOGISTS , 2016. Vol. 197, no 5, 1937-1944 p.
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Cell and Molecular Biology
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URN: urn:nbn:se:liu:diva-132484DOI: 10.4049/jimmunol.1600297ISI: 000385002300041PubMedID: 27456481OAI: oai:DiVA.org:liu-132484DiVA: diva2:1046262
Available from: 2016-11-13 Created: 2016-11-12 Last updated: 2016-11-13

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Somasundaram, RajeshSigvardsson, Mikael
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