Molecular Epidemiology of Rotavirus in Four Provinces of Angola Before Vaccine Introduction
2016 (English)In: Journal of Medical Virology, ISSN 0146-6615, E-ISSN 1096-9071, Vol. 88, no 9, 1511-1520 p.Article in journal (Refereed) Published
Angola is a sub-Saharan country in southern Africa highly affected by diarrhoeal disease with limited epidemiological data regarding etiologic agents. This study was performed during 2012-2013, prior to rotavirus vaccine introduction, with the objective to detect and characterize the rotavirus strains circulating in four provinces of the country: Huambo, Luanda, Zaire, and Cabinda. A high rotavirus detection rate (35%, 117/334) was observed. G1 was the most common G-genotype (83.6%), whereas P (50.9%) followed by P (38.8%) were the most common P-types. G1P was identified as the predominant combination (50%), followed by the unusual G1P (29.3%). Strains such G2P, G8P, G9P, and G12P were also found in lower frequencies (5.2-1.7%). The P strains did not cluster in the phylogenetic trees according to their geographic origin or even the corresponding G-genotype, suggesting a limited number of recent introductions and extensive reassortment events. Our results represent the first report on rotavirus genotype profiles in Angola, showing a wide circulation of the unusual genotype G1P, and underline the importance of RV surveillance after the vaccine introduction. (C) 2016 Wiley Periodicals, Inc.
Place, publisher, year, edition, pages
WILEY-BLACKWELL , 2016. Vol. 88, no 9, 1511-1520 p.
genotypes; diarrhoeal disease; children
IdentifiersURN: urn:nbn:se:liu:diva-132542DOI: 10.1002/jmv.24510ISI: 000385718800006PubMedID: 26946356OAI: oai:DiVA.org:liu-132542DiVA: diva2:1046365
Funding Agencies|Angolan Ministry of Health2016-11-142016-11-132016-11-14