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Stress-induced release of matrix metalloproteinase-9 in patients with coronary artery disease: The possible influence of cortisol
Linköping University, Department of Medical and Health Sciences, Division of Cardiovascular Medicine. Linköping University, Faculty of Medicine and Health Sciences.
Linköping University, Faculty of Medicine and Health Sciences. Linköping University, Department of Medical and Health Sciences, Division of Cardiovascular Medicine.
Linköping University, Department of Medical and Health Sciences, Division of Cardiovascular Medicine. Linköping University, Faculty of Medicine and Health Sciences.
Linköping University, Department of Medical and Health Sciences, Division of Community Medicine. Linköping University, Faculty of Medicine and Health Sciences.
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2016 (English)In: Psychoneuroendocrinology, ISSN 0306-4530, E-ISSN 1873-3360, Vol. 73, p. 117-124Article in journal (Refereed) Published
Abstract [en]

Stress and inflammation are both important risk factors for coronary artery disease (CAD). However, the susceptibility to stress-induced inflammation and its determinants have been little explored in patients with CAD. Here, our aim was to study the stress-induced inflammatory response, more precisely the early release of matrix metalloproteinase (MMP)-9, and its association with cortisol response in patients with CAD. Sixty-four patients underwent a standardized laboratory stress test. The stress-induced release of MMP-9 was closely associated with the release of other neutrophil-associated proteins, MMP-8 and myeloperoxidase (MPO). It also showed a large variation among patients, as did cortisol. Twenty minutes after stress, a negative association between changes in MMP-9 and cortisol was seen (p amp;lt; 0.01). In vitro, dexamethasone reduced the IL-8-mediated release of MMP-9 from neutrophils, indicating that glucocorticoids may exert rapid effects on neutrophil activation. Further characterization of patients revealed that stress-induced release of MMP-9 was related to leukocyte telomere shortening and increased ultrasound assessed plaque occurrence in the carotid arteries, but not to other characteristics such as age, gender or psychological background factors. The susceptibility to stress-induced release of MMP-9 may thus have impact on disease phenotype. Stress tests can be useful to identify CAD patients in need of novel prevention and treatment strategies. (C) 2016 Published by Elsevier Ltd.

Place, publisher, year, edition, pages
PERGAMON-ELSEVIER SCIENCE LTD , 2016. Vol. 73, p. 117-124
Keywords [en]
Coronary artery disease; Stress; Inflammation; Cortisol; Matrix metalloproteinase; Neutrophil
National Category
Neurology
Identifiers
URN: urn:nbn:se:liu:diva-132516DOI: 10.1016/j.psyneuen.2016.07.219ISI: 000385324800014PubMedID: 27494070OAI: oai:DiVA.org:liu-132516DiVA, id: diva2:1046464
Available from: 2016-11-14 Created: 2016-11-13 Last updated: 2018-03-27

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Lundberg, AnnaJönsson, SimonKristenson, MargaretaJonasson, Lena
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Division of Cardiovascular MedicineFaculty of Medicine and Health SciencesDivision of Community MedicineDepartment of Cardiology in Linköping
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