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High levels of endogenous lipid mediators (N-acylethanolamines) in women with chronic widespread pain during acute tissue trauma
Linköping University, Department of Medical and Health Sciences, Division of Community Medicine. Linköping University, Faculty of Medicine and Health Sciences.
Linköping University, Department of Medical and Health Sciences, Division of Community Medicine. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Pain and Rehabilitation Center.
Linköping University, Department of Medical and Health Sciences. Linköping University, Faculty of Medicine and Health Sciences.
Linköping University, Department of Medical and Health Sciences, Division of Community Medicine. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Pain and Rehabilitation Center.
2016 (English)In: Molecular Pain, ISSN 1744-8069, E-ISSN 1744-8069, Vol. 12, no 1744806916662886Article in journal (Refereed) Published
Abstract [en]

Although chronic widespread musculoskeletal pain is a significant health problem, the molecular mechanisms involved in developing and maintaining chronic widespread musculoskeletal pain are poorly understood. Central sensitization mechanisms maintained by stimuli from peripheral tissues such as muscle have been suggested. Lipid mediators with anti-inflammatory characteristics such as endogenous ligands of peroxisome proliferator activating receptor-alpha, oleoylethanolamide, and palmitoylethanolamide are suggested to regulate nociceptive transmission from peripheral locations on route towards the central nervous system. This case-control study investigates the levels of anti-inflammatory lipids in microdialysis samples collected during the first 2 h after microdialysis probe insertion and explores the association of these lipids with different pain characteristics in women with chronic widespread musculoskeletal pain (n = 17) and female healthy controls (n = 19). The levels of oleoylethanolamide, palmitoylethanolamide, and stearoylethanolamide were determined. During sampling of dialysate, pain ratings were conducted using a numeric rating scale. Pain thresholds were registered from upper and lower parts of the body. Oleoylethanolamide and stearoylethanolamide levels were significantly higher (p amp;lt;= 0.05) in chronic widespread musculoskeletal pain at all time points. Numeric rating scale correlated with levels of stearoylethanolamide in chronic widespread musculoskeletal pain. Higher levels of lipid mediators could reflect an altered tissue reactivity in response to microdialysis probe insertion in chronic widespread musculoskeletal pain.

Place, publisher, year, edition, pages
SAGE PUBLICATIONS INC , 2016. Vol. 12, no 1744806916662886
Keyword [en]
Chronic widespread pain; microdialysis; trapezius muscle; tissue trauma; lipid mediators
National Category
Medicinal Chemistry
Identifiers
URN: urn:nbn:se:liu:diva-132687DOI: 10.1177/1744806916662886ISI: 000386444700002PubMedID: 27531672OAI: oai:DiVA.org:liu-132687DiVA: diva2:1048140
Note

Funding Agencies|Swedish Research Council [K2015-99x-21874-05-4]; Swedish Council for Working Life and Social Research [2010-0913]; County Council of Ostergotland; AFA Insurance

Available from: 2016-11-20 Created: 2016-11-18 Last updated: 2016-12-07

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Stensson, NiclasGhafouri, BijarGhafouri, NazdarGerdle, Björn
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Division of Community MedicineFaculty of Medicine and Health SciencesPain and Rehabilitation CenterDepartment of Medical and Health Sciences
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