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Gene polymorphism in DNA repair genes XRCC1 and XRCC6 and association with colorectal cancer in Swedish patients
Jonköping University, Sweden.
Regional Jönköping County, Sweden.
Linköping University, Department of Medical and Health Sciences, Division of Drug Research. Linköping University, Faculty of Medicine and Health Sciences. Regional Jönköping County, Sweden.
Regional Jönköping County, Sweden.
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2016 (English)In: Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS), ISSN 0903-4641, E-ISSN 1600-0463, Vol. 124, no 9, 736-740 p.Article in journal (Refereed) Published
Abstract [en]

The DNA repair genes XRCC1 and XRCC6 have been proposed to participate in the pathological process of cancer by modulating the DNA repair capacity. This study evaluated the susceptibility of the single-nucleotide polymorphisms (SNPs) XRCC1 (rs25487, G amp;gt; A) and XRCC6 (rs2267437, C amp;gt; G) to colorectal cancer (CRC) and their association with clinical parameters in Swedish patients with CRC. Using the TaqMan system, these SNPs were screened in 452 patients and 464 controls. No significant difference in genotype distribution was found between the patients and controls, or any significant association with cancer-specific or disease-free survival in patients. However, we showed that the carriers of allele A in XRCC1 (rs25487, G amp;gt; A) were connected with a higher risk of disseminated CRC (Odds Ratio = 1.64; 95% Confidence Interval = 1.12-2.41, p = 0.012).

Place, publisher, year, edition, pages
WILEY-BLACKWELL , 2016. Vol. 124, no 9, 736-740 p.
Keyword [en]
DNA repair; XRCC1; XRCC6; Single-nucleotide polymorphism; colorectal cancer
National Category
Cancer and Oncology
Identifiers
URN: urn:nbn:se:liu:diva-132682DOI: 10.1111/apm.12563ISI: 000383581700002PubMedID: 27328741OAI: oai:DiVA.org:liu-132682DiVA: diva2:1048196
Note

Funding Agencies|Futurum the Academy of Healthcare; County Council of Jonkoping, Sweden; Foundation of Clinical Cancer Research, Jonkoping Sweden

Available from: 2016-11-21 Created: 2016-11-18 Last updated: 2016-11-21

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Slind Olsen, Renate
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Division of Drug ResearchFaculty of Medicine and Health Sciences
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