liu.seSearch for publications in DiVA
Change search
ReferencesLink to record
Permanent link

Direct link
Post-mortem concentrations of drugs determined in femoral blood in single-drug fatalities compared with multi-drug poisoning deaths
Linköping University, Department of Medical and Health Sciences, Division of Drug Research. Linköping University, Faculty of Medicine and Health Sciences.
Swedish National Board Forens Med, Department Forens Genet and Forens Toxicol, Linkoping, Sweden.
Linköping University, Department of Medical and Health Sciences, Division of Drug Research. Linköping University, Faculty of Medicine and Health Sciences. Swedish National Board Forens Med, Department Forens Genet and Forens Toxicol, Linkoping, Sweden.
2016 (English)In: Forensic Science International, ISSN 0379-0738, E-ISSN 1872-6283, Vol. 267, 96-103 p.Article in journal (Refereed) Published
Abstract [en]

Background: Reference concentrations of drugs in post-mortem femoral blood furnishes useful information when poisoning (intoxication) deaths are investigated. However, few publications compare the concentrations of drugs in single-drug fatalities with multi-drug intoxications. This article attempts to fill this gap in knowledge. Methods: We searched a national forensic toxicology database (TOXBASE) and found N = 13,963 deaths attributed by pathologists to intoxication by drugs (poisoning). The manner of death, whether accidental, suicidal or undetermined intent, was also available. To compare drug concentrations in living and deceased persons, we used information from people arrested for driving under the influence of drugs (DUID). Results: The percentage of drug intoxication deaths classified as undetermined intent decreased and accidental overdose deaths increased during the study period. In 2010 manner of death was considered accidental, suicidal or undetermined, in 41%, 30% and 28% of victims, respectively. Most of the deceased had taken multiple drugs (mean three drugs/case) and four or more drugs were identified in 35% of deaths. In single-drug fatalities ethanol (1585), morphine (114), citalopram (28), propoxyphene (51), flunitrazepam (70), propiomazine (46), tramadol (20) and zopiclone (15) were most prevalent. Alprazolam and diazepam were common findings in multi-drug deaths, although these benzodiazepines were rarely encountered in mono-drug intoxication deaths. Median blood concentrations were appreciably higher (2-10 fold) in single-drug fatalities compared with multi-drug deaths. The blood concentrations in DUID suspects were mostly lower than in the multi-drug poisoning deaths. Conclusion: This compilation of femoral blood concentrations of drugs in poisoning deaths provides a useful reference material, because we have distinguished between mono-drug intoxication deaths and poisoning with multiple-drugs. (C) 2016 Elsevier Ireland Ltd. All rights reserved.

Place, publisher, year, edition, pages
ELSEVIER IRELAND LTD , 2016. Vol. 267, 96-103 p.
Keyword [en]
Autopsy; Drug-related deaths; Intoxication; Multi-drug deaths; Poisonings; Mono-drug fatalities
National Category
Forensic Science
Identifiers
URN: urn:nbn:se:liu:diva-132673DOI: 10.1016/j.forsciint.2016.08.015ISI: 000386335100017PubMedID: 27591717OAI: oai:DiVA.org:liu-132673DiVA: diva2:1048309
Available from: 2016-11-21 Created: 2016-11-18 Last updated: 2016-11-21

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Jones, A Wayne
By organisation
Division of Drug ResearchFaculty of Medicine and Health Sciences
In the same journal
Forensic Science International
Forensic Science

Search outside of DiVA

GoogleGoogle Scholar

Altmetric score

Total: 12 hits
ReferencesLink to record
Permanent link

Direct link