liu.seSearch for publications in DiVA
Change search
ReferencesLink to record
Permanent link

Direct link
Progesterone receptor positivity is a predictor of long-term benefit from adjuvant tamoxifen treatment of estrogen receptor positive breast cancer
Sahlgrens Acad, Sweden; Southern Alvsborg Hospital, Sweden.
Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Health and Developmental Care, Regional Cancer Center South East Sweden.
Karolinska University Hospital, Sweden; Karolinska Institute, Sweden; Regional Cancer Centre Stockholm Gotland, Sweden.
St Göran Hospital, Sweden.
Show others and affiliations
2016 (English)In: Breast Cancer Research and Treatment, ISSN 0167-6806, E-ISSN 1573-7217, Vol. 160, no 2, 313-322 p.Article in journal (Refereed) Published
Abstract [en]

The independent predictive information from progesterone receptor (PgR) positivity for breast cancer treated with tamoxifen has been questioned after an overview by the Early Breast Cancer Trialists Collaborative Group (EBCTCG). However, the studies in the overview were to a large content performed before modern PgR immunohistochemistry (IHC) was developed. We therefore investigated the predictive value of PgR determined with IHC in estrogen receptor (ER)-positive tumors from patients participating in the Stockholm trial of adjuvant tamoxifen therapy. The Stockholm Breast Cancer Study Group conducted a randomized trial during 1976 through 1990 comparing adjuvant tamoxifen versus control. The patients were stratified according to tumor size and lymph node status in high-risk and low-risk groups. In this study, we evaluated 618 patients with ER-positive "low-risk" breast cancer (size aecurrency sign 30 mm, lymph node-negative) for whom PgR was determined by IHC at one pathology laboratory. The median time of follow-up was 21 years. Patients with ER-positive tumors that were also PgR-positive by IHC did benefit from tamoxifen, while we could not show any long-term benefit for those with tumors positive for ER only (recurrence rate ratio 0.43, 95 % CI 0.29-0.62 and 0.87, 95 % CI 0.52-1.46, respectively). We further investigated the influence of different levels of PgR positivity on recurrence risk. The results show that at all receptor levels with aeyen10 % stained PgR-positive cells, the patients did benefit from tamoxifen. There was no clear linear trend in benefit with increasing proportion of stained cells. PgR positivity determined by IHC is a marker indicating long-term benefit from adjuvant tamoxifen in patients with ER-positive tumors.

Place, publisher, year, edition, pages
SPRINGER , 2016. Vol. 160, no 2, 313-322 p.
Keyword [en]
Breast cancer; Tamoxifen; Estrogen receptor; Progesterone receptor
National Category
Cancer and Oncology
Identifiers
URN: urn:nbn:se:liu:diva-132653DOI: 10.1007/s10549-016-4007-5ISI: 000386370400012PubMedID: 27722840OAI: oai:DiVA.org:liu-132653DiVA: diva2:1048385
Note

Funding Agencies|Swedish Cancer Society; Swedish Breast Cancer Association; Cancer Research Foundations of Radiumhemmet; Cancer Society in Stockholm; King Gustav V Jubilee Clinical Research Foundation; County Council of Ostergotland; Onkologiska Klinikernas i Linkoping Forskningsfond

Available from: 2016-11-21 Created: 2016-11-18 Last updated: 2016-12-07

Open Access in DiVA

fulltext(919 kB)0 downloads
File information
File name FULLTEXT01.pdfFile size 919 kBChecksum SHA-512
c16f16c08478bda2e398ce092b571ab6c30a3414cd49ccddf13befe97ed6ea91ae2a36fafb657b581c310b2924b79d9c0480f64876e54d2e69126e0672fc6cfb
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Fohlin, HelenaStål, Olle
By organisation
Division of Clinical SciencesFaculty of Medicine and Health SciencesRegional Cancer Center South East SwedenDepartment of Oncology
In the same journal
Breast Cancer Research and Treatment
Cancer and Oncology

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 11 hits
ReferencesLink to record
Permanent link

Direct link