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A TPA-caged precursor of (imino)coumarin for "turn-on" fluorogenic detection of Cu+
Linköping University, Department of Physics, Chemistry and Biology, Molecular Surface Physics and Nano Science. Linköping University, Faculty of Science & Engineering.
Linköping University, Department of Physics, Chemistry and Biology. Linköping University, Faculty of Science & Engineering. Tongji University, Peoples R China.
Anhui University, Peoples R China.
Linköping University, Department of Physics, Chemistry and Biology, Molecular Surface Physics and Nano Science. Linköping University, Faculty of Science & Engineering.
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2016 (English)In: Analytica Chimica Acta, ISSN 0003-2670, E-ISSN 1873-4324, Vol. 933, 189-195 p.Article in journal (Refereed) Published
Abstract [en]

We strategize to utilize the precursors of (imino) coumarin fluorophores to deliver novel reactive Cu+ probes, where tris[(2-pyridyl)-methyl] amine (TPA) works as a reactive receptor towards Cu+. To verify this strategy, CP1, a representative probe and relevant sensing behaviors towards Cu+ are presented here. CP1 features good solubility and fast response for monitoring labile copper in aqueous solution and live cells. The sensing mechanism of CP1 is determined by HPLC titration and mass spectrometric analysis. The probe CP1 exhibits a 60-fold fluorescence enhancement and a detection limitation of 10.8 nM upon the detection of Cu+. CP1 is further applied for imaging labile copper in live cells. This work provides a starting point for future development of Cu+ probes, based on in situ formation of (imino) coumarin scaffolds, as well as their further investigations of copper signaling and biological events. (C) 2016 Elsevier B.V. All rights reserved.

Place, publisher, year, edition, pages
ELSEVIER SCIENCE BV , 2016. Vol. 933, 189-195 p.
Keyword [en]
Fluorogenic probe; Copper ions; (Imino)coumarin; Reaction-based fluorescence
National Category
Analytical Chemistry
Identifiers
URN: urn:nbn:se:liu:diva-132867DOI: 10.1016/j.aca.2016.05.031ISI: 000380849400021PubMedID: 27497012OAI: oai:DiVA.org:liu-132867DiVA: diva2:1052352
Note

Funding Agencies|Swedish Research Council (VR) [621-2013-5357]; National Natural Science Foundation of China [21577098]; Knut and Alice Wallenberg Foundation (KAW) [2012.0083]; Science and Technology Development Fund, Macao S.A.R (FDCT) [052/2015/A2]; Swedish Government strategic faculty grant in material science (SFO, MATLIU) in Advanced Functional Materials (AFM) (VR) [5.1-2015-5959]; Centre in Nano science and Nanotechnology (CeNano)

Available from: 2016-12-06 Created: 2016-11-30 Last updated: 2016-12-06

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