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Female Sex Hormones Influence the Febrile Response Induced by Lipopolysaccharide, Cytokines and Prostaglandins but not by Interleukin-1 beta in Rats
University of Federal Parana, Brazil.
University of Federal Parana, Brazil.
Linköping University, Department of Clinical and Experimental Medicine, Division of Cell Biology. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Local Health Care Services in Central Östergötland, Department of Emergency Medicine.
Linköping University, Department of Clinical and Experimental Medicine, Division of Cell Biology. Linköping University, Faculty of Medicine and Health Sciences.
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2016 (English)In: Journal of neuroendocrinology (Print), ISSN 0953-8194, E-ISSN 1365-2826, Vol. 28, no 10Article in journal (Refereed) Published
Abstract [en]

There are differences in the immune response, and particularly fever, between males and females. In the present study, we investigated how the febrile responses induced by lipopolysaccharide (LPS) and different endogenous pyrogens were affected by female gonadal hormones. The febrile response to i.p. injection of LPS (50g/kg) was 40% lower in female rats compared to male or ovariectomised (OVX) female rats. Accordingly, oestrogen replacement in OVX animals reduced LPS-induced fever. Treatment with the prostaglandin synthesis inhibitor indomethacin (2mg/kg, i.p. 30min before) reduced the febrile response induced by LPS in both OVX (88%) and sham-operated (71%) rats. In line with the enhanced fever in OVX rats, there was increased expression of cyclooxygenase-2 (COX-2) in the hypothalamus and elevated levels of prostaglandin E-2 (PGE(2)). In addition, OVX rats were hyper-responsive to PGE(2) injected i.c.v. By contrast to the enhanced fever in response to LPS and PGE(2), the febrile response induced by i.c.v. injection of interleukin (IL)-1 was unaffected by ovariectomy, whereas the responses induced by tumour necrosis factor (TNF)- and macrophage inflammatory protein (MIP)-1 were completely abrogated. These results suggest that the mediators involved in the febrile response in females are similar to males, although the reduction of female hormones may decrease the responsiveness of some mediators such as TNF- and MIP-1. Compensatory mechanisms may be activated in females after ovariectomy such as an augmented synthesis of COX-2 and PGE(2).

Place, publisher, year, edition, pages
Wiley-Blackwell, 2016. Vol. 28, no 10
Keyword [en]
fever, oestrogen, tumour necrosis factor-α, macrophage-inflammatory protein-1 beta
National Category
Neurosciences
Identifiers
URN: urn:nbn:se:liu:diva-132858DOI: 10.1111/jne.12414ISI: 000387066900003PubMedID: 27483048OAI: oai:DiVA.org:liu-132858DiVA: diva2:1052399
Note

Funding Agencies|Fundacao de Amparo a Pesquisa do Maranhao (FAPEMA) [00431/12]; Doctoral Abroad Program (PDSE)/CAPES, Brazil

Available from: 2016-12-06 Created: 2016-11-30 Last updated: 2017-03-28Bibliographically approved

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Björk Wilhelms, DanielStojakovic, AndreaEngblom, David
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Division of Cell BiologyFaculty of Medicine and Health SciencesDepartment of Emergency Medicine
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