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Ionotropic glutamate receptors in spinal nociceptive processing.
Department of Anatomy and Centre for Molecular Biology and NeuroscienceUniversity of Oslo, Oslo, Norway.ORCID iD: 0000-0003-3584-7829
2009 (English)In: Molecular Neurobiology, ISSN 0893-7648, E-ISSN 1559-1182, Vol. 40, no 3, 260-288 p.Article in journal (Refereed) Published
Abstract [en]

Glutamate is the predominant excitatory transmitter used by primary afferent synapses and intrinsic neurons in the spinal cord dorsal horn. Accordingly, ionotropic glutamate receptors mediate basal spinal transmission of sensory, including nociceptive, information that is relayed to supraspinal centers. However, it has become gradually more evident that these receptors are also crucially involved in short- and long-term plasticity of spinal nociceptive transmission, and that such plasticity have an important role in the pain hypersensitivity that may result from tissue or nerve injury. This review will cover recent findings on pre- and postsynaptic regulation of synaptic function by ionotropic glutamate receptors in the dorsal horn and how such mechanisms contribute to acute and chronic pain.

Place, publisher, year, edition, pages
Springer, 2009. Vol. 40, no 3, 260-288 p.
Keyword [en]
Hyperalgesia; Nociception; AMPA receptors; NMDA receptors; Kainate receptors; Long-term potentiation; Presynaptic regulation; Synaptic plasticity
National Category
Neurosciences
Identifiers
URN: urn:nbn:se:liu:diva-133052DOI: 10.1007/s12035-009-8086-8ISI: 000271851300006PubMedID: 19876771Scopus ID: 2-s2.0-70849132787OAI: oai:DiVA.org:liu-133052DiVA: diva2:1054573
Available from: 2016-12-08 Created: 2016-12-08 Last updated: 2016-12-13Bibliographically approved

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